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RX ITEM-Mercaptopurine 50Mg Tab 60 By Teva Pharma

NDC 00093-5510-06 UPC/GTIN No.3-00935-51006-4 Mfg.Part No.551006BRAND: MERCAPTOPURINE NDC: 00093-5510-06,93551006 UPC: 3-00935-51006-4,300935510064 Teva Pharmaceuticals USAOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Mercaptopurine 50Mg Tab 60 By Teva Pharma

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item No.:RX252882 NDC No.93551006 UPC No.:300935510064 NDC No. 00093-5510-06 UPC/GTIN No. 3-00935-51006-4 MPN 551006 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx252882 Mercaptopurine 50mg Tab 60 by TTeva Pharma Item No. 3252882 NDC No. 00093551006 UPC No. 300935510064 Other Name Purinethol,Pu

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PURINETHOL- mercaptopurine tablet
Gate Pharmaceuticals

CAUTION

PURINETHOL (mercaptopurine) is a potent drug. It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the responsible physician is experienced with the risks of PURINETHOL and knowledgeable in assessing response to chemotherapy.

DESCRIPTION

PURINETHOL (mercaptopurine) was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories.



Mercaptopurine, known chemically as 1,7-dihydro-6H -purine-6-thione monohydrate, is an analogue of the purine bases adenine and hypoxanthine. PURINETHOL is available in tablet form for oral administration. Each scored tablet contains 50 mg mercaptopurine and the inactive ingredients corn and potato starch, lactose, magnesium stearate, and stearic acid.

CLINICAL PHARMACOLOGY

Mechanism of Action
Mercaptopurine (6-MP) competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to thioinosinic acid (TIMP). This intracellular nucleotide inhibits several reactions involving inosinic acid (IMP), including the conversion of IMP to xanthylic acid (XMP) and the conversion of IMP to adenylic acid (AMP) via adenylosuccinate (SAMP). In addition, 6-methylthioinosinate (MTIMP) is formed by the methylation of TIMP. Both TIMP and MTIMP have been reported to inhibit glutamine-5-phosphoribosylpyrophosphate amidotransferase, the first enzyme unique to the de novo pathway for purine ribonucleotide synthesis. Experiments indicate that radiolabeled mercaptopurine may be recovered from the DNA in the form of deoxythioguanosine. Some mercaptopurine is converted to nucleotide derivatives of 6-thioguanine (6-TG) by the sequential actions of inosinate (IMP) dehydrogenase and xanthylate (XMP) aminase, converting TIMP to thioguanylic acid (TGMP).

Animal tumors that are resistant to mercaptopurine often have lost the ability to convert mercaptopurine to TIMP. However, it is clear that resistance to mercaptopurine may be acquired by other means as well, particularly in human leukemias.

It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death. INDICATIONS AND USAGE

PURINETHOL (mercaptopurine) is indicated for maintenance therapy of acute lymphatic (lymphocytic, lymphoblastic) leukemia as part of a combination regimen. The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric or adult).

PURINETHOL is not effective for prophylaxis or treatment of central nervous system leukemia.

PURINETHOL is not effective in acute myelogenous leukemia, chronic lymphatic leukemia, the lymphomas (including Hodgkins Disease), or solid tumors.

NDC 00093-5510-06 UPC/GTIN No.3-00935-51006-4 Mfg.Part No.551006
RX ITEM-Mercaptopurine 50Mg Tab 60 By Te
NDC 00093-5510-06 UPC/GTIN No.3-00935-51006-4 Mfg.Part No.551006

BRAND: MERCAPTOPURINE NDC: 00093-5510-06,93551006 UPC: 3-00935-51006-4,300935510064 Teva Pharmaceuticals USA
Mercaptopurine 50Mg Tab 60 By Teva Pharm
BRAND: MERCAPTOPURINE NDC: 00093-5510-06,93551006 UPC: 3-00935-51006-4,300935510064 Teva Pharmaceuticals USA

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MERCAPTOPURINE ORAL TABLE
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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