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Rx Item-Meclizine 25Mg Tab 1000 By Jubilant Cadista Pharma

NDC 59746-0121-10 UPC/GTIN No.3-59746-12110-5 Mfg.Part No.12110BRAND: MECLIZINE NDC: 59746-0121-10,59746012110 UPC: 3-59746-12110-5,359746121105 Jubilant Cadista PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Meclizine 25Mg Tab 1000 By Jubilant Cadista Pharma

$401.32$218.16

Item No.:RX039289/A, Item No. RX039289, 039289, NDC No.: 59746-0121-10, 59746-121-10, 5974612110, 59746012110, 0121-10, 012110 UPC No. 3-59746-12110-5, 359746-121105, 359746121105, Rx Item-Meclizine 25Mg Tab 1000 By Jubilant Cadista Pharma Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Central Nervous System Agents- Antiemetic/Antivertigo AgentsDrug Class: 56220800 Antihistamines (Gi Drugs)
4041600 Piperazine Derivative

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MECLIZINE HYDROCHLORIDE- meclizine hydrochloride tablet
Epic Pharma, LLC

DESCRIPTION

Chemically, meclizine hydrochloride is 1-(p -chloro-?-phenylbenzyl)-4-(m -methylbenzyl) piperazine dihydrochloride monohydrate. C25 H27 CIN2 �2HCl�H2 0 M.W. 481.89

Meclizine hydrochloride tablets, USP are available in two different strengths, 12.5 mg and 25 mg. Inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium and magnesium stearate. The 12.5 mg tablet also contains FD&C Blue #1 Aluminum Lake.

CLINICAL PHARMACOLOGY

Meclizine hydrochloride is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.

Pharmacokinetics
The available pharmacokinetic information for meclizine following oral administration has been summarized from published literature.

Absorption
Meclizine is absorbed after oral administration with maximum plasma concentrations reaching at a median Tmax value of 3 hours post-dose (range: 1.5 to 6 hours) for the tablet dosage form.

Distribution
Drug distribution characteristics for meclizine in humans are unknown.

Metabolism
The metabolic fate of meclizine in humans is unknown. In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP 2D6 was found to be the dominant enzyme for metabolism of meclizine.

The genetic polymorphism of CYP2D6 that results in extensive-, poor-, intermediate- and ultrarapid metabolizer phenotypes could contribute to large inter-individual variability in meclizine exposure.

Elimination
Meclizine has a plasma elimination half-life of about 5-6 hours in humans.

INDICATIONS

Based on a review of this drug by the National Academy of Sciences � National Research Council and/or other information, FDA has classified the indications as follows:

Effective: Management of nausea and vomiting, and dizziness associated with motion sickness.

Final classification of the less than effective indications requires further investigation. DOSAGE AND ADMINISTRATION

Motion Sickness
The initial dose of 25 to 50 mg of meclizine hydrochloride should be taken one hour prior to embarkation for protection against motion sickness. Thereafter, the dose may be repeated every 24 hours for the duration of the journey.

NDC 59746-0121-10 UPC/GTIN No.3-59746-12110-5 Mfg.Part No.12110
RX ITEM-Meclizine 25Mg Tab 1000 By Jubil
NDC 59746-0121-10 UPC/GTIN No.3-59746-12110-5 Mfg.Part No.12110

BRAND: MECLIZINE NDC: 59746-0121-10,59746012110 UPC: 3-59746-12110-5,359746121105 Jubilant Cadista Pharma
Meclizine 25Mg Tab 1000 By Jubilant Cadi
BRAND: MECLIZINE NDC: 59746-0121-10,59746012110 UPC: 3-59746-12110-5,359746121105 Jubilant Cadista Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MECLIZINE HCL ORAL TABLET
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.