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Rx Item-Meclizine 12.5Mg Tab 1000 By Amneal Pharma

NDC 65162-0441-11 UPC/GTIN No.3-65162-44111-6 Mfg.Part No.44111BRAND: MECLIZINE NDC: 65162-0441-11,65162044111 UPC: 3-65162-44111-6,365162441116 Amneal Pharma Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Meclizine 12.5Mg Tab 1000 By Amneal Pharma

$325.60$195.58

Item No.:RX172561 NDC No.65162044111 UPC No.:365162441116 NDC No. 65162-0441-11 UPC/GTIN No. 3-65162-44111-6 MPN 44111 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx172561 Meclizine 12.5mg Tab 1000 by Amneal Pharma Item No. 3172561 NDC No. 65162044111 UPC No. 365162441116 Other Name Antivert,Bo

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MECLIZINE HYDROCHLORIDE- meclizine hydrochloride tablet
Epic Pharma, LLC

DESCRIPTION

Chemically, meclizine hydrochloride is 1-(p -chloro-?-phenylbenzyl)-4-(m -methylbenzyl) piperazine dihydrochloride monohydrate. C25 H27 CIN2 �2HCl�H2 0 M.W. 481.89

Meclizine hydrochloride tablets, USP are available in two different strengths, 12.5 mg and 25 mg. Inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium and magnesium stearate. The 12.5 mg tablet also contains FD&C Blue #1 Aluminum Lake.

CLINICAL PHARMACOLOGY

Meclizine hydrochloride is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.

Pharmacokinetics
The available pharmacokinetic information for meclizine following oral administration has been summarized from published literature.

Absorption
Meclizine is absorbed after oral administration with maximum plasma concentrations reaching at a median Tmax value of 3 hours post-dose (range: 1.5 to 6 hours) for the tablet dosage form.

Distribution
Drug distribution characteristics for meclizine in humans are unknown.

Metabolism
The metabolic fate of meclizine in humans is unknown. In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP 2D6 was found to be the dominant enzyme for metabolism of meclizine.

The genetic polymorphism of CYP2D6 that results in extensive-, poor-, intermediate- and ultrarapid metabolizer phenotypes could contribute to large inter-individual variability in meclizine exposure.

Elimination
Meclizine has a plasma elimination half-life of about 5-6 hours in humans.

INDICATIONS

Based on a review of this drug by the National Academy of Sciences � National Research Council and/or other information, FDA has classified the indications as follows:

Effective: Management of nausea and vomiting, and dizziness associated with motion sickness.

Final classification of the less than effective indications requires further investigation. DOSAGE AND ADMINISTRATION

Motion Sickness
The initial dose of 25 to 50 mg of meclizine hydrochloride should be taken one hour prior to embarkation for protection against motion sickness. Thereafter, the dose may be repeated every 24 hours for the duration of the journey.

NDC 65162-0441-11 UPC/GTIN No.3-65162-44111-6 Mfg.Part No.44111
RX ITEM-Meclizine 12.5Mg Tab 1000 By Amn
NDC 65162-0441-11 UPC/GTIN No.3-65162-44111-6 Mfg.Part No.44111

BRAND: MECLIZINE NDC: 65162-0441-11,65162044111 UPC: 3-65162-44111-6,365162441116 Amneal Pharma
Meclizine 12.5Mg Tab 1000 By Amneal Phar
BRAND: MECLIZINE NDC: 65162-0441-11,65162044111 UPC: 3-65162-44111-6,365162441116 Amneal Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MECLIZINE HCL ORAL TABLET
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.