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RX ITEM-Magnesium Sulfate 1 Gm 100U/Ml PIGGYBACK 24X100Ml By Hospira Worldwide

NDC 00409-6727-23 UPC/GTIN No.3-04096-72723-5 Mfg.Part No.672723BRAND: MAGNESIUM SULFATE NDC: 00409-6727-23,409672723 UPC: 3-04096-72723-5,304096727235 Hospira Worldwide Inc.Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Magnesium Sulfate 1 Gm 100U/Ml PIGGYBACK 24X100Ml By Hospira Worldwide

$277.61$199.98

item No.:RX150151 NDC No.409672723 UPC No.:304096727235 NDC No.00409-6727-23 UPC/GTIN No.3-04096-72723-5 MPN 672723 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx150151 Magnesium Sulfate-D5W 1 G/100 ml P/B 24X100ml by Hospira Worldwide Item No.3150151 NDC No.00409672723 UPC No.304096727235 Other

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MAGNESIUM SULFATE IN DEXTROSE- magnesium sulfate heptahydrate injection, solution
Hospira, Inc.


Flexible Plastic Container

For Intravenous Use Only

Rx only

DESCRIPTION

Magnesium Sulfate in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate and dextrose in water for injection. Each 100 mL contains 1 or 2 g magnesium sulfate heptahydrate and dextrose, hydrous 5 g in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). It is available in 1% and 2% concentrations. See HOW SUPPLIED section for the content and characteristics of available dosage forms and sizes.



Magnesium Sulfate, USP heptahydrate is chemically designated MgSO4 7H2 O, colorless crystals or white powder freely soluble in water.

Dextrose, USP is chemically designated D-glucose, monohydrate (C6 H12 O6 H2 O), a hexose sugar freely soluble in water. It has the following structural formula:

structural formula Dextrose, USP
Molecular weight 198.17.

Water for Injection, USP is chemically designated H2 O.

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25C/77F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

CLINICAL PHARMACOLOGY

Magnesium (Mg++) is an important cofactor for enzymatic reactions and plays an important role in neurochemical transmission and muscular excitability.

Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium is said to have a depressant effect on the central nervous system, but it does not adversely affect the mother, fetus or neonate when used as directed in eclampsia or pre-eclampsia. Normal serum magnesium levels range from 1.3 to 2.1 mEq/liter.

As serum magnesium rises above 4 mEq/liter, the deep tendon reflexes are first decreased and then disappear as the serum level approaches 10 mEq/liter. At this level respiratory paralysis may occur. Heart block also may occur at this or lower serum levels of magnesium.

Magnesium acts peripherally to produce vasodilation. With low doses only flushing and sweating occur, but larger doses cause lowering of blood pressure. The central and peripheral effects of magnesium poisoning are antagonized to some extent by intravenous administration of calcium.

With intravenous administration the onset of anticonvulsant action is immediate and lasts about 30 minutes. Following intramuscular administration the onset of action occurs in about one hour and persists for three to four hours. Effective anticonvulsant serum levels range from 2.5 to 7.5 mEq/liter.

Pharmacokinetics:

Absorption: Intravenously administered magnesium is immediately absorbed.

Distribution: Approximately 1-2% of total body magnesium is located in the extracellular fluid space. Magnesium is 30% bound to albumin.

Metabolism: Magnesium is not metabolized.

Excretion: Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.

Special Populations:

Renal Insufficiency: Magnesium is excreted solely by the kidney. In patients with severe renal insufficiency, the dose should be lower and frequent serum magnesium levels must be obtained (see DOSAGE AND ADMINISTRATION).

Hepatic Insufficiency: Magnesium is excreted solely by the kidney. No dosing adjustments are necessary in hepatic insufficiency.

Drug-Drug Interactions: Drug induced renal losses of magnesium occur with the following drugs or drug classes:

Aminoglycosides Amphotericin B
Cyclosporine Diuretics
Digitalis Cisplatin
Alcohol

INDICATIONS AND USAGE

Magnesium Sulfate in 5% Dextrose Injection, USP is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

NDC 00409-6727-23 UPC/GTIN No.3-04096-72723-5 Mfg.Part No.672723
RX ITEM-Magnesium Sulfate 1 Gm 100U/Ml P
NDC 00409-6727-23 UPC/GTIN No.3-04096-72723-5 Mfg.Part No.672723

BRAND: MAGNESIUM SULFATE NDC: 00409-6727-23,409672723 UPC: 3-04096-72723-5,304096727235 Hospira Worldwide Inc.
Magnesium Sulfate 1 Gm 100U/Ml PIGGYBACK
BRAND: MAGNESIUM SULFATE NDC: 00409-6727-23,409672723 UPC: 3-04096-72723-5,304096727235 Hospira Worldwide Inc.

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MAGNESIUM SULFATE/D5W INT
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.