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Rx Item-Liothyronine 10 Mcg/Ml Vial 1Ml By X Gen Pharma

NDC 39822-0151-01 UPC/GTIN No.3-39822-01511-5 Mfg.Part No.15101BRAND: LIOTHYRONINE NDC: 39822-0151-01,39822015101 UPC: 3-39822-01511-5,339822015115  X/Gen PharmaceuticalOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Liothyronine 10 Mcg/Ml Vial 1Ml By X Gen Pharma

$481.25$437.43

Item No.:RX038568 NDC No.39822015101 UPC No.:339822015115 NDC No. 39822-0151-01 UPC/GTIN No. 3-39822-01511-5 MPN 15101 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx038568 Liothyronine 10 mcg/ml Vial 1ml by X/Gen Pharma Item No. 3038568 NDC No. 39822015101 UPC No. 339822015115 Other Name Cytome

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TRIOSTAT- liothyronine sodium injection
JHP Pharmaceuticals LLC

PRESCRIBING INFORMATION
DESCRIPTION

Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4 , levothyroxine) sodium or triiodothyronine (T3 , liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Both hormones are stored in the thyroid colloid as thyroglobulin and released into the circulation. The major source of T3 has been shown to be peripheral deiodination of T4 . T3 is bound less firmly than T4 in the serum, enters peripheral tissues more readily, and binds to specific nuclear receptor(s) to initiate hormonal, metabolic effects. T4 is the prohormone which is deiodinated to T3 for hormone activity.

Thyroid hormone preparations belong to two categories: (1) natural hormonal preparations derived from animal thyroid, and (2) synthetic preparations. Natural preparations include desiccated thyroid and thyroglobulin. Desiccated thyroid is derived from domesticated animals that are used for food by man (either beef or hog thyroid), and thyroglobulin is derived from thyroid glands of the hog.

Triostat (liothyronine sodium injection) (T3 ) contains liothyronine (L-triiodothyronine or L-T3 ), a synthetic form of a natural thyroid hormone, as the sodium salt.
L-Tyrosine, 0-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt

In euthyroid patients, 25 mcg of liothyronine is equivalent to approximately 1 grain of desiccated thyroid or thyroglobulin and 0.1 mg of L-thyroxine.

Each mL of Triostat in amber-glass vials contains, in sterile non-pyrogenic aqueous solution, liothyronine sodium equivalent to 10 mcg of liothyronine; alcohol, 6.8% by volume; anhydrous citric acid, 0.175 mg; ammonia, 2.19 mg, as ammonium hydroxide.
CLINICAL PHARMACOLOGY

Thyroid hormones enhance oxygen consumption by most tissues of the body and increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. In vitro studies indicate that T3 increases aerobic mitochondrial function, thereby increasing the rates of synthesis and utilization of myocardial high-energy phosphates. This, in turn, stimulates myosin ATPase and reduces tissue lactic acidosis. Thus, thyroid hormones exert a profound influence on virtually every organ system in the body and are of particular importance in the development of the central nervous system.
Triostat Indications and Usage

Triostat (liothyronine sodium injection) (T3 ) is indicated in the treatment of myxedema coma/precoma.

Triostat can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.
CONTRAINDICATIONS

Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency or untreated thyrotoxicosis. Thyroid hormone preparations are also generally contraindicated in patients with hypersensitivity to any of the active or extraneous constituents of these preparations; however, there is no well-documented evidence in the literature of true allergic or idiosyncratic reactions to thyroid hormone.
DOSAGE AND ADMINISTRATION
Adults

Myxedema coma is usually precipitated in the hypothyroid patient of long standing by intercurrent illness or drugs such as sedatives and anesthetics and should be considered a medical emergency. Therapy should be directed at the correction of electrolyte disturbances, possible infection, or other intercurrent illness in addition to the administration of intravenous liothyronine (T3 ). Simultaneous glucocorticosteroids are required.

Triostat (liothyronine sodium injection) (T3 ) is for intravenous administration only. It should not be given intramuscularly or subcutaneously.

Prompt administration of an adequate dose of intravenous liothyronine (T3 ) is important in determining clinical outcome.

Initial and subsequent doses of Triostat should be based on continuous monitoring of the patient's clinical status and response to therapy.

Triostat doses should normally be administered at least four hours�and not more than 12 hours�apart.

Administration of at least 65 mcg/day of intravenous liothyronine (T3 ) in the initial days of therapy was associated with lower mortality.

There is limited clinical experience with intravenous liothyronine (T3 ) at total daily doses exceeding 100 mcg/day.

NDC 39822-0151-01 UPC/GTIN No.3-39822-01511-5 Mfg.Part No.15101
RX ITEM-Liothyronine 10 Mcg/Ml Vial 1Ml
NDC 39822-0151-01 UPC/GTIN No.3-39822-01511-5 Mfg.Part No.15101

BRAND: LIOTHYRONINE NDC: 39822-0151-01,39822015101 UPC: 3-39822-01511-5,339822015115  X/Gen Pharmaceutical
Liothyronine 10 Mcg/Ml Vial 1Ml By X Gen
BRAND: LIOTHYRONINE NDC: 39822-0151-01,39822015101 UPC: 3-39822-01511-5,339822015115 X/Gen Pharmaceutical

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
LIOTHYRONINE SODIUM INTRA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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