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Rx Item-Isosorbide Mononitrate ER 120Mg Tab 100 By Kremers Urban

NDC 62175-0129-37 UPC/GTIN No.3-62175-12937-6 Mfg.Part No.12937BRAND: ISOSORBIDE MONONITRATE NDC: 62175-0129-37,62175012937 UPC: 3-62175-12937-6,362175129376 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Isosorbide Mononitrate ER 120Mg Tab 100 By Kremers Urban

$76.08$34.77

Item No.:RX898890/a, Item No. RX898890, 898890, NDC No.: 62175-0129-37, 62175-129-37, 6217512937, 62175012937, 0129-37, 012937 UPC No. 3-62175-12937-6, 362175-129376, 362175129376, Rx Item-Isosorbide Mononitrate ER 120Mg Tab 100 By Kremers Urban Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Cardiovascular Agents Antianginal AgentsDrug Class: 24120800 Nitrates And Nitrites

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IMDUR- isosorbide mononitrate tablet, extended release
Schering Corporation
DESCRIPTION

Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.

IMDUR� Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, hydrogenated castor oil, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose and talc.

The molecular formula of ISMN is C6 H9 NO6 and the molecular weight is 191.14. The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate
ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90�C, and an optical rotation of +144� (2% in water, 20�C).

Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane.
CLINICAL PHARMACOLOGY
Mechanism of Action

The IMDUR product is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate.

The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.
IMDUR Indications and Usage

IMDUR Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
DOSAGE AND ADMINISTRATION

The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of a 60 mg tablet) or 60 mg (given as a single tablet) once daily. After several days, the dosage may be increased to 120 mg (given as a single 120 mg tablet or as two 60 mg tablets) once daily. Rarely, 240 mg may be required. The daily dose of IMDUR Tablets should be taken in the morning on arising. IMDUR Extended Release Tablets should not be chewed or crushed and should be swallowed together with a half-glassful of fluid. Do not break the 30 mg tablet.
Information for Patients

Patients should be told that the antianginal efficacy of IMDUR Tablets can be maintained by carefully following the prescribed schedule of dosing. For most patients, this can be accomplished by taking the dose on arising.

As with other nitrates, daily headaches sometimes accompany treatment with isosorbide mononitrate. In patients who get these headaches, the headaches are a marker of the activity of the drug. Patients should resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide mononitrate, since loss of headache may be associated with simultaneous loss of antianginal efficacy. Aspirin or acetaminophen often successfully relieves isosorbide mononitrate-induced headaches with no deleterious effect on isosorbide mononitrate�s antianginal efficacy.

NDC 62175-0129-37 UPC/GTIN No.3-62175-12937-6 Mfg.Part No.12937
RX ITEM-Isosorbide Mononitrate ER 120Mg
NDC 62175-0129-37 UPC/GTIN No.3-62175-12937-6 Mfg.Part No.12937

BRAND: ISOSORBIDE MONONITRATE NDC: 62175-0129-37,62175012937 UPC: 3-62175-12937-6,362175129376
Isosorbide Mononitrate ER 120Mg Tab 100
BRAND: ISOSORBIDE MONONITRATE NDC: 62175-0129-37,62175012937 UPC: 3-62175-12937-6,362175129376

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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