Rx Item-Ironotecan 100Mg/5Ml Vial 5Ml By Actavis Pharma(Teva) Gen Camptosar

IRINOTECAN HYDROCHLORIDE- irinotecan hydrochloride injection, solution
Sagent Pharmaceuticals

WARNING: DIARRHEA and MYELOSUPPRESSION

Early and late forms of diarrhea can occur. Early diarrhea may be accompanied by cholinergic symptoms which may be prevented or ameliorated by atropine. Late diarrhea can be life threatening and should be treated promptly with loperamide. Monitor patients with diarrhea and give fluid and electrolytes as needed. Institute antibiotic therapy if patients develop ileus, fever, or severe neutropenia. Interrupt irinotecan hydrochloride injection and reduce subsequent doses if severe diarrhea occurs.
Severe myelosuppression may occur.
1 INDICATIONS AND USAGE

Irinotecan Hydrochloride Injection, USP is indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.
2 DOSAGE AND ADMINISTRATION

2.1 Colorectal Single Agent Regimens 1 and 2


Administer Irinotecan Hydrochloride Injection, USP as a 90-minute intravenous infusion. The currently recommended regimens are shown in Table 1.

A reduction in the starting dose by one dose level of Irinotecan Hydrochloride Injection, USP may be considered for patients with any of the following conditions: prior pelvic/abdominal radiotherapy, performance status of 2, or increased bilirubin levels. Dosing for patients with bilirubin >2 mg/dL cannot be recommended because there is insufficient information to recommend a dose in these patients.

RX ITEM-Ironotecan 100Mg/5Ml Vial 5Ml By
Item No.:RX414011 NDC No.45963061455 45963-0614-55 45963-0=614-55 UPC No.:345963614551 NDC No. 45963-0614-55 UPC/GTIN No. 3-45963-61455-1 345963-614551 345963614551 MPN 61455

Ironotecan 100Mg/5Ml Vial 5Ml By Actavis
Item No.:RX414011 NDC No.45963061455 45963-0614-55 45963-0=614-55 UPC No.:345963614551 NDC No. 45963-0614-55 UPC/GTIN No. 3-45963-61455-1 345963-614551 345963614551 MPN 61455

IRINOTECAN HCL INTRAVEN V
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