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Rx Item-Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance

Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.NDC 57237-0023-01 UPC/GTIN No.3-57237-02301-3 Mfg.Part No.2301BRAND: GLYBURIDE NDC: 57237-0023-01,57237002301 UPC: 3-57237-02301-3,357237023013

Rx Item-Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance

$88.60$9.99

Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-02301-3 357237-023013 357237023013 MPN 2301 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx488200 Glyburide-Metformin 1.25/250mg Tab 100 by Citron Pharma Item No. 34

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GLUCOVANCE- glyburide and metformin hydrochloride tablet, film coated
Bristol-Myers Squibb Company

1.25 mg/250 mg
2.5 mg/500 mg5 mg/500 mg

DESCRIPTION

GLUCOVANCE� (Glyburide and Metformin HCl) Tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glyburide and metformin hydrochloride.

Glyburide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glyburide is 1-[[p -[2-(5-chloro-o -anisamido)ethyl]phenyl]sulfonyl]-3-cyclo-hexylurea. Glyburide is a white to off-white crystalline compound with a molecular formula of C23 H28 ClN3 O5 S and a molecular weight of 494.01. The glyburide used in GLUCOVANCE has a particle size distribution of 25% undersize value not more than 6 ?m, 50% undersize value not more than 7 to 10 ?m, and 75% undersize value not more than 21 ?m
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N -dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or ?-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4 H12 ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68
CLINICAL PHARMACOLOGY

Mechanism of Action
GLUCOVANCE combines glyburide and metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes.

Glyburide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in patients with type 2 diabetes, the blood glucose-lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs.

Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023
Glyburide-Metformin 1.25 250Mg
Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023

Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023
Glyburide-Metformin 1.25 250Mg
Glyburide-Metformin 1.25 250Mg Tab 100 By Citron Pharma Gen Glucovance Item No.:RX488200 NDC No.57237002301 57237-023-01 5723702301 UPC No.:357237023013 NDC No. 57237-0023-01 UPC/GTIN No. 3-57237-023

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NDC 57237-0023-01 UPC/GTIN No.3-57237-02301-3 Mfg.Part No.2301
RX ITEM-Glyburide-Metformin 1.25 250Mg T
NDC 57237-0023-01 UPC/GTIN No.3-57237-02301-3 Mfg.Part No.2301

BRAND: GLYBURIDE NDC: 57237-0023-01,57237002301 UPC: 3-57237-02301-3,357237023013
Glyburide-Metformin 1.25 250Mg Tab 100 B
BRAND: GLYBURIDE NDC: 57237-0023-01,57237002301 UPC: 3-57237-02301-3,357237023013