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RX ITEM-Glyburide-Metformin 1.25 250Mg Tab 100 By Aurobindo Pharma

NDC 65862-0080-01 UPC/GTIN No.3-65862-08001-1 Mfg.Part No.8001BRAND: GLYBURIDE-METFORMIN NDC: 65862-0080-01,65862008001 UPC: 3-65862-08001-1,365862080011 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Glyburide-Metformin 1.25 250Mg Tab 100 By Aurobindo Pharma

$0.00

item No.:RX086266/a NDC No.65862008001 UPC No.:365862080011 NDC No. 65862-0080-0 UPC/GTIN No. 3-65862-08001-1 MPN 8001 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx086266 Glyburide-Metformin 1.25/250mg Tab 100 by Aurobindo Pharma Item No. 3086266 NDC No. 65862008001 UPC No. 365862080011 Other

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GLUCOVANCE- glyburide and metformin hydrochloride tablet, film coated
Bristol-Myers Squibb Company

1.25 mg/250 mg
2.5 mg/500 mg5 mg/500 mg

DESCRIPTION

GLUCOVANCE� (Glyburide and Metformin HCl) Tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glyburide and metformin hydrochloride.

Glyburide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glyburide is 1-[[p -[2-(5-chloro-o -anisamido)ethyl]phenyl]sulfonyl]-3-cyclo-hexylurea. Glyburide is a white to off-white crystalline compound with a molecular formula of C23 H28 ClN3 O5 S and a molecular weight of 494.01. The glyburide used in GLUCOVANCE has a particle size distribution of 25% undersize value not more than 6 ?m, 50% undersize value not more than 7 to 10 ?m, and 75% undersize value not more than 21 ?m
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N -dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or ?-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4 H12 ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68
CLINICAL PHARMACOLOGY

Mechanism of Action
GLUCOVANCE combines glyburide and metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes.

Glyburide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in patients with type 2 diabetes, the blood glucose-lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs.

Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

NDC 65862-0080-01 UPC/GTIN No.3-65862-08001-1 Mfg.Part No.8001
RX ITEM-Glyburide-Metformin 1.25 250Mg T
NDC 65862-0080-01 UPC/GTIN No.3-65862-08001-1 Mfg.Part No.8001

BRAND: GLYBURIDE-METFORMIN NDC: 65862-0080-01,65862008001 UPC: 3-65862-08001-1,365862080011
Glyburide-Metformin 1.25 250Mg Tab 100 B
BRAND: GLYBURIDE-METFORMIN NDC: 65862-0080-01,65862008001 UPC: 3-65862-08001-1,365862080011

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.