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Rx Item-Gliadel 7.7 192.3 Waf 8 By Otn Mckesson Speciality

NDC 24338-0050-08 UPC/GTIN No.3-24338-05008-8 Mfg.Part No.5008BRAND: GLIADEL NDC: 24338-0050-08,24338005008 UPC: 3-24338-05008-8,324338050088 Otn / Mckesson SpecialityOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Gliadel 7.7 192.3 Waf 8 By Otn Mckesson Speciality

$39588.58$37703.41

Item No.:RX339717 NDC No.24338005008 UPC No.:324338050088 NDC No. 24338-0050-08 UPC/GTIN No. 3-24338-05008-8 MPN 5008 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx339717 Gliadel 7.7/192.3 Waf 8 by Otn / Mckesson Speciality Item No. 3339717 NDC No. 24338005008 UPC No. 324338050088 Other Nam

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GLIADEL- carmustine wafer
Eisai Inc.

DESCRIPTION

GLIADEL� Wafer (polifeprosan 20 with carmustine implant) is a sterile, off-white to pale yellow wafer approximately 1.45 cm in diameter and 1 mm thick. Each wafer contains 192.3 mg of a biodegradable polyanhydride copolymer and 7.7 mg of carmustine [1,3-bis (2-chloroethyl)-1-nitrosourea, or BCNU]. Carmustine is a nitrosourea oncolytic agent. The copolymer, polifeprosan 20, consists of poly[bis(p-carboxyphenoxy) propane: sebacic acid] in a 20:80 molar ratio and is used to control the local delivery of carmustine. Carmustine is homogeneously distributed in the copolymer matrix.



The structural formula for polifeprosan 20 is:


gliadel-01
(click image for full-size original)
The structural formula for carmustine is:


gliadel-02
gliadel-01 gliadel-02
CLINICAL PHARMACOLOGY

GLIADEL� Wafer is designed to deliver carmustine directly into the surgical cavity created when a brain tumor is resected. On exposure to the aqueous environment of the resection cavity, the anhydride bonds in the copolymer are hydrolyzed, releasing carmustine, carboxyphenoxypropane, and sebacic acid. The carmustine released from GLIADEL� Wafer diffuses into the surrounding brain tissue and produces an antineoplastic effect by alkylating DNA and RNA.

Carmustine has been shown to degrade both spontaneously and metabolically. The production of an alkylating moiety, hypothesized to be chloroethyl carbonium ion, leads to the formation of DNA cross-links.

The tumoricidal activity of GLIADEL� Wafer is dependent on release of carmustine to the tumor cavity in concentrations sufficient for effective cytotoxicity.

NDC 24338-0050-08 UPC/GTIN No.3-24338-05008-8 Mfg.Part No.5008
RX ITEM-Gliadel 7.7 192.3 Waf 8 By Otn M
NDC 24338-0050-08 UPC/GTIN No.3-24338-05008-8 Mfg.Part No.5008

BRAND: GLIADEL NDC: 24338-0050-08,24338005008 UPC: 3-24338-05008-8,324338050088 Otn / Mckesson Speciality
Gliadel 7.7 192.3 Waf 8 By Otn Mckesson
BRAND: GLIADEL NDC: 24338-0050-08,24338005008 UPC: 3-24338-05008-8,324338050088 Otn / Mckesson Speciality

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CARMUSTINE IN POLIFEPROSA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.