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Rx Item-Ganirelix Ace 250Mcg 0.5 Syringe 0.5Ml By Merck

NDC 00052-0301-51 UPC/GTIN No.3-00520-30151-6 Mfg.Part No.30151BRAND: GANIRELIX ACE NDC: 00052-0301-51,52030151 UPC: 3-00520-30151-6,300520301516 Merck & Co.Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Ganirelix Ace 250Mcg 0.5 Syringe 0.5Ml By Merck

$259.79$240.00

Item No.:RX754604 NDC No.52030151 UPC No.:300520301516 NDC No. 00052-0301-51 UPC/GTIN No. 3-00520-30151-6 MPN 30151 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx754604 Ganirelix Ace 250Mcg/0.5 Syringe 0.5ml by Merck Item No. 3754604 NDC No. 00052030151 UPC No. 300520301516 Other Name Ganirelix

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GANIRELIX ACETATE- ganirelix acetate injection, solution
Organon USA Inc.


FOR SUBCUTANEOUS USE ONLY

DESCRIPTION

Ganirelix Acetate Injection is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Ganirelix Acetate is derived from native GnRH with substitutions of amino acids at positions 1, 2, 3, 6, 8, and 10 to form the following molecular formula of the peptide: N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N9 ,N10 -diethyl-D-homoarginyl-L-leucyl-N9 ,N10 -diethyl-L-homoarginyl-L-prolyl-D-alanylamide acetate. The molecular weight for Ganirelix Acetate is 1570.4 as an anhydrous free base. The structural formula is as follows:



Ganirelix Acetate

Image of Ganirelix Acetate Chemical Structure
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Ganirelix Acetate Injection is supplied as a colorless, sterile, ready-to-use, aqueous solution intended for SUBCUTANEOUS administration only. Each sterile, prefilled syringe contains 250 mcg/0.5 mL of Ganirelix Acetate, 0.1 mg glacial acetic acid, 23.5 mg mannitol, and water for injection adjusted to pH 5.0 with acetic acid, NF and/or sodium hydroxide, NF.

CLINICAL PHARMACOLOGY

The pulsatile release of GnRH stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The frequency of LH pulses in the mid and late follicular phase is approximately 1 pulse per hour. These pulses can be detected as transient rises in serum LH. At midcycle, a large increase in GnRH release results in an LH surge. The midcycle LH surge initiates several physiologic actions including: ovulation, resumption of meiosis in the oocyte, and luteinization. Luteinization results in a rise in serum progesterone with an accompanying decrease in estradiol levels.

Ganirelix Acetate acts by competitively blocking the GnRH receptors on the pituitary gonadotroph and subsequent transduction pathway. It induces a rapid, reversible suppression of gonadotropin secretion. The suppression of pituitary LH secretion by Ganirelix Acetate is more pronounced than that of FSH. An initial release of endogenous gonadotropins has not been detected with Ganirelix Acetate, which is consistent with an antagonist effect. Upon discontinuation of Ganirelix Acetate, pituitary LH and FSH levels are fully recovered within 48 hours.

NDC 00052-0301-51 UPC/GTIN No.3-00520-30151-6 Mfg.Part No.30151
RX ITEM-Ganirelix Ace 250Mcg 0.5 Syringe
NDC 00052-0301-51 UPC/GTIN No.3-00520-30151-6 Mfg.Part No.30151

BRAND: GANIRELIX ACE NDC: 00052-0301-51,52030151 UPC: 3-00520-30151-6,300520301516 Merck & Co.
Ganirelix Ace 250Mcg 0.5 Syringe 0.5Ml B
BRAND: GANIRELIX ACE NDC: 00052-0301-51,52030151 UPC: 3-00520-30151-6,300520301516 Merck & Co.

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
GANIRELIX ACETATE SUB-Q S
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.