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Rx Item-Forane isoflurane INHALATION LIQUID 99.9 % Liq 6X250Ml By Baxter Pharma

NDC 10019-0360-60 UPC/GTIN No.3-10019-36060-7 Mfg.Part No.36060BRAND: FORANE NDC: 10019-0360-60,10019036060 UPC: 3-10019-36060-7,310019360607 Baxter Pharma USAOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Forane isoflurane INHALATION LIQUID 99.9 % Liq 6X250Ml By Baxter Pharma

$414.36$376.48

item No.:RX360305 NDC No.10019036060 10019-360-60 1001936060 UPC No.:310019360607 NDC No. 10019-0360-60 UPC/GTIN No. 3-10019-36060-7 310019360607 310019-360607 MPN 36060 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx360305 Forane 99.9% Liq 6X250ml by Baxter Acc Item No. 3360305 NDC No. 1001903

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FORANE- isoflurane inhalant
Baxter Healthcare Corporation

DESCRIPTION

FORANE (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:

Forane structural formula
Some physical constants are:

Molecular weight

184.5

Boiling point at 760 mm Hg

48.5�C

Refractive index n 20 D

1.2990-1.3005

Specific gravity 25�/25�C

1.496

Vapor pressure in mm Hg**

20�C

238

25�C

295

30�C

367

35�C

450

**Equation for vapor pressure calculation:

log10 Pvap = A + B/T where:

A = 8.056

B = -1664.58

T = �C + 273.16 (Kelvin)



Partition coefficients at 37�C

Water/gas

0.61

Blood/gas

1.43

Oil/gas

90.8

Partition coefficients at 25�C � rubber and plastic

Conductive rubber/gas

62.0

Butyl rubber/gas

75.0

Polyvinyl chloride/gas

110.0

Polyethylene/gas

~2.0

Polyurethane/gas

~1.4

Polyolefin/gas

~1.1

Butyl acetate/gas

~2.5

Purity by gas chromatography

>99.9%

Lower limit of flammability in oxygen or nitrous oxide at 9 joules/sec. and 23�C

None

Lower limit of flammability in oxygenor nitrous oxide at 900 joules/sec. and 23�C

Greater than useful concentration in anesthesia.

Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.

CLINICAL PHARMACOLOGY

FORANE is an inhalation anesthetic. The MAC (minimum alveolar concentration) in man is as follows:

Age

100% Oxygen

70% N2 0

26�4

1.28

0.56

44�7

1.15

0.50

64�5

1.05

0.37

Induction of and recovery from isoflurane anesthesia are rapid. Isoflurane has a mild pungency which limits the rate of induction, although excessive salivation or tracheobronchial secretions do not appear to be stimulated. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia may be changed rapidly with isoflurane. Isoflurane is a profound respiratory depressant. RESPIRATION MUST BE MONITORED CLOSELY AND SUPPORTED WHEN NECESSARY. As anesthetic dose is increased, tidal volume decreases and respiratory rate is unchanged. This depression is partially reversed by surgical stimulation, even at deeper levels of anesthesia. Isoflurane evokes a sigh response reminiscent of that seen with diethyl ether and enflurane, although the frequency is less than with enflurane.

Blood pressure decreases with induction of anesthesia but returns toward normal with surgical stimulation. Progressive increases in depth of anesthesia produce corresponding decreases in blood pressure. Nitrous oxide diminishes the inspiratory concentration of isoflurane required to reach a desired level of anesthesia and may reduce the arterial hypotension seen with isoflurane alone. Heart rhythm is remarkably stable. With controlled ventilation and normal PaCO2 , cardiac output is maintained despite increasing depth of anesthesia, primarily through an increase in heart rate which compensates for a reduction in stroke volume. The hypercapnia which attends spontaneous ventilation during isoflurane anesthesia further increases heart rate and raises cardiac output above awake levels. Isoflurane does not sensitize the myocardium to exogenously administered epinephrine in the dog. Limited data indicate that subcutaneous injection of 0.25 mg of epinephrine (50 mL of 1:200,000 solution) does not produce an increase in ventricular arrhythmias in patients anesthetized with isoflurane.

Muscle relaxation is often adequate for intra-abdominal operations at normal levels of anesthesia. Complete muscle paralysis can be attained with small doses of muscle relaxants. ALL COMMONLY USED MUSCLE RELAXANTS ARE MARKEDLY POTENTIATED WITH ISOFLURANE, THE EFFECT BEING MOST PROFOUND WITH THE NONDEPOLARIZING TYPE. Neostigmine reverses the effect of nondepolarizing muscle relaxants in the presence of isoflurane. All commonly used muscle relaxants are compatible with isoflurane.

Isoflurane can produce coronary vasodilation at the arteriolar level in selected animal models; the drug is probably also a coronary dilator in humans. Isoflurane, like some other coronary arteriolar dilators, has been shown to divert blood from collateral dependent myocardium to normally perfused areas in an animal model ("coronary steal"). Clinical studies to date evaluating myocardial ischemia, infarction and death as outcome parameters have not established that the coronary arteriolar dilation property of isoflurane is associated with coronary steal or myocardial ischemia in patients with coronary artery disease.

Pharmacokinetics:
Isoflurane undergoes minimal biotransformation in man. In the postanesthesia period, only 0.17% of the isoflurane taken up can be recovered as urinary metabolites.

INDICATIONS AND USAGE

FORANE may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia.

NDC 10019-0360-60 UPC/GTIN No.3-10019-36060-7 Mfg.Part No.36060
RX ITEM-Forane 99.9% Liq 6X250Ml By Baxt
NDC 10019-0360-60 UPC/GTIN No.3-10019-36060-7 Mfg.Part No.36060

BRAND: FORANE NDC: 10019-0360-60,10019036060 UPC: 3-10019-36060-7,310019360607 Baxter Pharma USA
Forane 99.9% Liq 6X250Ml By Baxter Pharm
BRAND: FORANE NDC: 10019-0360-60,10019036060 UPC: 3-10019-36060-7,310019360607 Baxter Pharma USA

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ISOFLURANE INHALATION LIQ
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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