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RX ITEM-Fomepizole 1G/Ml Vial 1.5Ml By Sandoz Pharma

NDC 00781-3182-73 UPC/GTIN No.3-07813-18273-3 Mfg.Part No.318273BRAND: FOMEPIZOLE NDC: 00781-3182-73,781318273 UPC: 3-07813-18273-3,307813182733 Sandoz/RxOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Fomepizole 1G/Ml Vial 1.5Ml By Sandoz Pharma

$0.00

item No.:RX932475 NDC No.781318273 UPC No.:307813182733 NDC No. 00781-3182-73 UPC/GTIN No. 3-07813-18273-3 MPN 318273 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx932475 Fomepizole 1 G/ml Vial 1.5ml by Sandoz Pharma Item No. 3932475 NDC No. 00781318273 UPC No. 307813182733 Other Name Fomepiz

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FOMEPIZOLE- fomepizole injection, solution
Mylan Institutional LLC

1.5 g/1.5 mL (1 g/mL)

Sterile

Rx only

Caution: Must be diluted prior to use.

DESCRIPTION

Fomepizole Injection is a competitive inhibitor of alcohol dehydrogenase.

The chemical name of fomepizole is 4-methylpyrazole. It has the molecular formula C4 H6 N2 and a molecular weight of 82.1. The structural formula is:

Fomepizole Chemical Structure


It is a clear to yellow liquid at room temperature. Its melting point is 25� C (77� F) and it may present in a solid form at room temperature. Fomepizole is soluble in water and very soluble in ethanol, diethyl ether, and chloroform. Each vial contains 1.5 mL (1 g/mL) of fomepizole.

CLINICAL PHARMACOLOGY

Mechanism of Action
Fomepizole is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

Ethylene glycol, the main component of most antifreezes and coolants, is metabolized to glycoaldehyde, which undergoes subsequent sequential oxidations to yield glycolate, glyoxylate, and oxalate. Glycolate and oxalate are the metabolic byproducts primarily responsible for the metabolic acidosis and renal damage seen in ethylene glycol toxicosis. The lethal dose of ethylene glycol in humans is approximately 1.4 mL/kg.

Methanol, the main component of windshield wiper fluid, is slowly metabolized via alcohol dehydrogenase to formaldehyde with subsequent oxidation via formaldehyde dehydrogenase to yield formic acid. Formic acid is primarily responsible for the metabolic acidosis and visual disturbances (e.g., decreased visual acuity and potential blindness) associated with methanol poisoning. A lethal dose of methanol in humans is approximately 1 to 2 mL/kg. INDICATIONS AND USAGE

Fomepizole injection is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis (see DOSAGE AND ADMINISTRATION

NDC 00781-3182-73 UPC/GTIN No.3-07813-18273-3 Mfg.Part No.318273
RX ITEM-Fomepizole 1G/Ml Vial 1.5Ml By S
NDC 00781-3182-73 UPC/GTIN No.3-07813-18273-3 Mfg.Part No.318273

BRAND: FOMEPIZOLE NDC: 00781-3182-73,781318273 UPC: 3-07813-18273-3,307813182733 Sandoz/Rx
Fomepizole 1G/Ml Vial 1.5Ml By Sandoz Ph
BRAND: FOMEPIZOLE NDC: 00781-3182-73,781318273 UPC: 3-07813-18273-3,307813182733 Sandoz/Rx

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
FOMEPIZOLE INTRAVEN VIAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.