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Rx Item-Flumazenil 0.1Mg/Ml Vial 10Ml By Fresenius Kabi USA

Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410BRAND: FLUMAZENIL NDC: 63323-0424-10,63323042410 UPC: 3-63323-42410-7,363323424107 Fresenius Kabi USA LlcOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Flumazenil 0.1Mg/Ml Vial 10Ml By Fresenius Kabi USA Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410

Rx Item-Flumazenil 0.1Mg/Ml Vial 10Ml By Fresenius Kabi USA

$74.88$71.31

Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx942545 Flumazenil 0.1mg/ml Vial 10ml by Fresenius Kabi USA Item No. 3942545 NDC No. 63323042410 UPC No. 363323424107 Other Name Ro

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FLUMAZENIL- flumazenil injection, solution
West-Ward Pharmaceuticals


FLUMAZENIL INJECTION, USP

Rx Only

DESCRIPTION

Flumazenil Injection, USP is a benzodiazepine receptor antagonist. Chemically, flumazenil is ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1 ,5-a](1,4) benzodiazepine-3-carboxylate. Flumazenil has an imidazobenzodiazepine structure, a calculated molecular weight of 303.3, and the following structural formula:

Image from Drug Label Content


Flumazenil is a white to off-white crystalline compound with an octanol: buffer partition coefficient of 14 to 1 at pH 7.4. It is insoluble in water but slightly soluble in acidic aqueous solutions. Flumazenil injection is available as a sterile parenteral dosage form for intravenous administration. Each mL contains 0.1 mg of flumazenil compounded with 1.8 mg of methylparaben, 0.2 mg of propylparaben, 0.9% sodium chloride, 0.01% edetate disodium, and 0.01% acetic acid; the pH is adjusted to approximately 4 with hydrochloric acid and/or, if necessary, sodium hydroxide.

CLINICAL PHARMACOLOGY

Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in man.

Flumazenil does not antagonize the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids.

In animals pretreated with high doses of benzodiazepines over several weeks, flumazenil elicited symptoms of benzodiazepine withdrawal, including seizures. A similar effect was seen in adult human subjects.

Pharmacodynamics
Intravenous flumazenil has been shown to antagonize sedation, impairment of recall, psychomotor impairment and ventilatory depression produced by benzodiazepines in healthy human volunteers.

The duration and degree of reversal of sedative benzodiazepine effects are related to the dose and plasma concentrations of flumazenil as shown in the following data from a study in normal volunteers.

Image from Drug Label Content
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Generally, doses of approximately 0.1 mg to 0.2 mg (corresponding to peak plasma levels of 3 to 6 ng/mL) produce partial antagonism, whereas higher doses of 0.4 to 1 mg (peak plasma levels of 12 to 28 ng/mL) usually produce complete antagonism in patients who have received the usual sedating doses of benzodiazepines. The onset of reversal is usually evident within 1 to 2 minutes after the injection is completed. Eighty percent response will be reached within 3 minutes, with the peak effect occurring at 6 to 10 minutes. The duration and degree of reversal are related to the plasma concentration of the sedating benzodiazepine as well as the dose of flumazenil given.

In healthy volunteers, flumazenil did not alter intraocular pressure when given alone and reversed the decrease in intraocular pressure seen after administration of midazolam.

Pharmacokinetics
After IV administration, plasma concentrations of flumazenil follow a two-exponential decay model. The pharmacokinetics of flumazenil are dose-proportional up to 100 mg.

Distribution
Flumazenil is extensively distributed in the extravascular space with an initial distribution half-life of 4 to 11 minutes and a terminal half-life of 40 to 80 minutes. Peak concentrations of flumazenil are proportional to dose, with an apparent initial volume of distribution of 0.5 L/kg. The volume of distribution at steady-state is 0.9 to 1.1 L/kg. Flumazenil is a weak lipophilic base. Protein binding is approximately 50% and the drug shows no preferential partitioning into red blood cells. Albumin accounts for two thirds of plasma protein binding.

Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410
RX ITEM-Flumazenil 0.1Mg/Ml Vial 10Ml By
Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410

BRAND: FLUMAZENIL NDC: 63323-0424-10,63323042410 UPC: 3-63323-42410-7,363323424107 Fresenius Kabi USA Llc
Flumazenil 0.1Mg/Ml Vial 10Ml By Freseni
BRAND: FLUMAZENIL NDC: 63323-0424-10,63323042410 UPC: 3-63323-42410-7,363323424107 Fresenius Kabi USA Llc

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
FLUMAZENIL INTRAVEN VIAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Flumazenil 0.1Mg/Ml Vial 10Ml By Fresenius Kabi USA Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410
Flumazenil 0.1Mg/Ml Vial 10Ml
Flumazenil 0.1Mg/Ml Vial 10Ml By Fresenius Kabi USA Item No.:RX942545 NDC No.63323042410 UPC No.:363323424107 NDC No. 63323-0424-10 UPC/GTIN No. 3-63323-42410-7 MPN 42410