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Rx Item-Dutoprol 50 12.5Mg Tab 30 By Astra Zeneca Pharma

NDC 00310-1095-30 UPC/GTIN No.3-03101-09530-3 Mfg.Part No.109530BRAND: DUTOPROL NDC: 00310-1095-30,310109530 UPC: 3-03101-09530-3,303101095303 Astra Zeneca PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Dutoprol 50 12.5Mg Tab 30 By Astra Zeneca Pharma

$286.80$273.14

Item No.:RX559096 NDC No.310109530 UPC No.:303101095303 NDC No.New 59212-0095-30 00310-1095-30 UPC/GTIN No. 3-03101-09530-3 MPN 109530 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx559096 Dutoprol 50/12.5mg Tab 30 by Astra Zeneca Pharma Item No. 559096 NDC No.New 59212-0095-30 00310109530 UPC N

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DUTOPROL- metoprolol succinate and hydrochlorothiazide tablet
Concordia Pharmaceuticals Inc

WARNING: CARDIAC ISCHEMIA AFTER ABRUPT DISCONTINUATION

Following abrupt discontinuation of therapy with beta adrenergic blockers, exacerbations of angina pectoris and myocardial infarction have occurred.

When discontinuing chronically administered DUTOPROL, particularly in patients with ischemic heart disease, gradually reduce the dose over a period of 1�2 weeks and monitor the patient. If angina markedly worsens or acute coronary insufficiency develops, promptly resume therapy, at least temporarily, and take other measures appropriate for the management of unstable angina. Warn patients against interruption or discontinuation of therapy without the physician�s advice.



Because coronary artery disease is common and may be unrecognized, avoid abrupt discontinuation of DUTOPROL therapy even in patients treated only for hypertension [see Warnings and Precautions (5.1)].

1 INDICATIONS AND USAGE

DUTOPROL (metoprolol succinate extended release and hydrochlorothiazide) is a combination tablet of metoprolol succinate, a beta adrenoceptor blocking agent and hydrochlorothiazide, a diuretic. DUTOPROL is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular (CV) events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol and hydrochlorothiazide.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program�s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy.

DUTOPROL may be administered with other antihypertensive agents.

2 DOSAGE AND ADMINISTRATION

2.1 Dosing Information
The recommended starting dose of DUTOPROL (metoprolol succinate extended release and hydrochlorothiazide) is 25 mg/12.5 mg taken orally once daily with or without food. Depending on the blood pressure response, the dose may be titrated at intervals of 2 weeks to a maximum recommended dose of 200 mg/25 mg (two DUTOPROL 100 mg/12.5 mg tablets) once daily [see Clinical Studies (14)].

For specific advice on blood pressure goals, see published guidelines, such as those of the National High Blood Pressure Education Program�s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

2.2 Use with and Switching from other Anti-Hypertensive Drugs
DUTOPROL may be administered with other antihypertensive drugs. Patients titrated to the individual components (metoprolol succinate and hydrochlorothiazide) may instead receive the corresponding dose of DUTOPROL.

A patient whose blood pressure is inadequately controlled by metoprolol succinate alone or hydrochlorothiazide alone may be switched to DUTOPROL.

3 DOSAGE FORMS AND STRENGTHS

25/12.5 mg tablets: Yellow, circular, biconvex, film-coated tablet engraved with �A" above �IH" on one side.

50/12.5 mg tablets: Light orange, circular, biconvex, film-coated tablet engraved with �A" above �IK" on one side.

100/12.5 mg tablets: Yellow, circular, biconvex, film-coated tablet engraved with �A" above �IL" on one side and scored on the other side.

NDC 00310-1095-30 UPC/GTIN No.3-03101-09530-3 Mfg.Part No.109530
RX ITEM-Dutoprol 50 12.5Mg Tab 30 By Ast
NDC 00310-1095-30 UPC/GTIN No.3-03101-09530-3 Mfg.Part No.109530

BRAND: DUTOPROL NDC: 00310-1095-30,310109530 UPC: 3-03101-09530-3,303101095303 Astra Zeneca Pharma
Dutoprol 50 12.5Mg Tab 30 By Astra Zenec
BRAND: DUTOPROL NDC: 00310-1095-30,310109530 UPC: 3-03101-09530-3,303101095303 Astra Zeneca Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
METOPROLOL SUCCINATE/HCTZ
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.