Please email us at [email protected] with our item No, NDC#, UPC# or the product link if you have any quetions. We are located in Oceanside, California. Search over 110,000 items by Name, Item No., NDC, UPC (without dashes) or by Mfg.Name. Please note, Prescription items can only be ordered by a Drug Manufacturer, Wholesaler, Hospital, Governmental Medical Facility, VA, Pharmacy, Physician, Physician Assistant, Nurse Practitioner, Dentist, Podiatrist, Optometrist, Veterinarian, Naturopath, Licensed Lab, Physical Therapist & Pharmacist in their scope of practice. No order will ship, unless you you have provided us the Medical License (and DEA Lic. in case of controlled drug) and we had verified that. Rx items can only be shipped to AZ, AR, CA, CT, DE, FL, GA, GU, HI, IL, KS, KY, LA, ME, MA, MI, NJ, NY, PA, PR, TX, TN, VA, WA, WI and WV. If you are an International Physician or Pharmacist, please contact us before ordering.


Menu

RX ITEM-Duoneb Inhala 0.5 3Mg 3 Solution 30X3Ml By Mylan Specialty Lp

NDC 49502-0672-30 UPC/GTIN No.3-49502-67230-9 Mfg.Part No.67230BRAND: DUONEB-INHALATION NDC: 49502-0672-30,49502067230 UPC: 3-49502-67230-9,349502672309 Mylan Specialty LpOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Duoneb Inhala 0.5 3Mg 3 Solution 30X3Ml By Mylan Specialty Lp

$0.00

item No.:RX087938 NDC No.49502067230 UPC No.:349502672309 NDC No. 49502-0672-30 UPC/GTIN No. 3-49502-67230-9 MPN 67230 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx087938 Duoneb Inhala 0.5/3mg/3 Solution 30X3ml by Mylan Specialty Lp Item No. 3087938 NDC No. 49502067230 UPC No. 349502672309 Oth

Have a question?

  Out of stock, please email us with the item number or product link at [email protected] for the quantity available, current pricing and eligibility to purchase.

DUONEB- ipratropium bromide and albuterol sulfate solution
Mylan Specialty

DuoNeb�

(Ipratropium Bromide 0.5 mg/Albuterol Sulfate 3.0 mg*)Inhalation Solution *Equivalent to 2.5 mg albuterol base

DESCRIPTION

The active components in DuoNeb� Inhalation Solution are albuterol sulfate and ipratropium bromide.

Albuterol sulfate, is a salt of racemic albuterol and a relatively selective ?2 -adrenergic bronchodilator chemically described as ?1 -[(tert-butylamino)methyl]-4-hydroxy-m-xylene-?, ?�-diol sulfate (2:1) (salt). It has a molecular weight of 576.7 and the empirical formula is (C13 H21 NO3 )2 �H2 SO4 . It is a white crystalline powder, soluble in water and slightly soluble in ethanol. The World Health Organization recommended name for albuterol base is salbutamol.

Figure 3 1-1. Chemical structure of albuterol sulfate.
(click image for full-size original)


Figure 3. 1-1. Chemical structure of albuterol sulfate.
Ipratropium bromide is an anticholinergic bronchodilator chemically described as 8-azoniabicyclo [3.2.1]-octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8methyl-8-(1-methylethyl)-, bromide, monohydrate (endo, syn)-, (�)-; a synthetic quaternary ammonium compound, chemically related to atropine. It has a molecular weight of 430.4 and the empirical formula is C20 H30 BrNO3 �H2 O. It is a white crystalline substance, freely soluble in water and lower alcohols, and insoluble in lipophilic solvents such as ether, chloroform, and fluorocarbons.

Figure 3. 1-2. Chemical structure of ipratropium bromide.
(click image for full-size original)
Figure 3. 1-2. Chemical structure of ipratropium bromide.
Each 3 mL vial of DuoNeb contains 3.0 mg (0.1%) of albuterol sulfate (equivalent to 2.5 mg (0.083%) of albuterol base) and 0.5 mg (0.017%) of ipratropium bromide in an isotonic, sterile, aqueous solution containing sodium chloride, hydrochloric acid to adjust to pH 4, and edetate disodium, USP (a chelating agent).

DuoNeb is a clear, colorless solution. It does not require dilution prior to administration by nebulization. For DuoNeb Inhalation Solution, like all other nebulized treatments, the amount delivered to the lungs will depend on patient factors, the jet nebulizer utilized, and compressor performance. Using the Pari-LC-Plus� nebulizer (with face mask or mouthpiece) connected to a PRONEB� compressor system, under in vitro conditions, the mean delivered dose from the mouth piece (% nominal dose) was approximately 46% of albuterol and 42% of ipratropium bromide at a mean flow rate of 3.6 L/min. The mean nebulization time was 15 minutes or less. DuoNeb should be administered from jet nebulizers at adequate flow rates, via face masks or mouthpieces (see DOSAGE AND ADMINISTRATION).

CLINICAL PHARMACOLOGY

DuoNeb Inhalation Solution is a combination of the ?2 -adrenergic bronchodilator, albuterol sulfate, and the anticholinergic bronchodilator, ipratropium bromide.

Albuterol sulfate
Mechanism of Action
The prime action of ?-adrenergic drugs is to stimulate adenyl cyclase, the enzyme that catalyzes the formation of cyclic-3?,5?-adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). The cAMP thus formed mediates the cellular responses. In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on ?2 -adrenergic receptors compared with isoproterenol. While it is recognized that ?2 -adrenergic receptors are the predominant receptors in bronchial smooth muscle, recent data indicated that 10% to 50% of the ?-receptors in the human heart may be ?2 -receptors. The precise function of these receptors, however, is not yet established. Albuterol has been shown in most controlled clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. Controlled clinical studies and other clinical experience have shown that inhaled albuterol, like other ?-adrenergic agonist drugs, can produce a significant cardiovascular effect in some patients.

NDC 49502-0672-30 UPC/GTIN No.3-49502-67230-9 Mfg.Part No.67230
RX ITEM-Duoneb Inhala 0.5 3Mg 3 Solution
NDC 49502-0672-30 UPC/GTIN No.3-49502-67230-9 Mfg.Part No.67230

BRAND: DUONEB-INHALATION NDC: 49502-0672-30,49502067230 UPC: 3-49502-67230-9,349502672309 Mylan Specialty Lp
Duoneb Inhala 0.5 3Mg 3 Solution 30X3Ml
BRAND: DUONEB-INHALATION NDC: 49502-0672-30,49502067230 UPC: 3-49502-67230-9,349502672309 Mylan Specialty Lp

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
IPRATROPIUM/ALBUTEROL SUL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.