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Rx Item-Differin 0.1% Gel 45Gm By Galderma Labs

NDC 00299-5910-45 UPC/GTIN No.3-02995-91045-7 Mfg.Part No.591045BRAND: DIFFERIN NDC: 00299-5910-45,299591045 UPC: 3-02995-91045-7,302995910457 Galderma Labs Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Differin 0.1% Gel 45Gm By Galderma Labs

$698.46$0.29

Item No.:RX936682 NDC No.299591045 UPC No.:302995910457 NDC No. 00299-5910-45 UPC/GTIN No. 3-02995-91045-7 MPN 591045 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx936682 Differin 0.1% Gel 45gm by Galderma Labs, Item No. 3936682 NDC No. 00299591045 UPC No. 302995910457 Other Name Adapalene

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DIFFERIN - adapalene cream
GALDERMA LABORATORIES, L.P

DESCRIPTION

DIFFERIN� (adapalene) Cream, 0.1%, contains adapalene 0.1% in an aqueous cream emulsion consisting of carbomer 934P, cyclomethicone, edetate disodium, glycerin, methyl glucose sesquistearate, methylparaben, PEG-20 methyl glucose sesquistearate, phenoxyethanol, propylparaben, purified water, squalane, and trolamine.

The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. It is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is C28 H28 O3 and molecular weight is 412.53. Adapalene is represented by the following structural formula.

p50448-1-chem-structp50448-1-chem-struct
CLINICAL PHARMACOLOGY

Mechanism of Action


Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.

Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Pharmacokinetics
Absorption of adapalene from DIFFERIN� Cream through human skin is low. In a pharmacokinetic study with six acne patients treated once daily for 5 days with 2 grams of DIFFERIN� Cream applied to 1000 cm2 of acne involved skin, there were no quantifiable amounts (limit of quantification = 0.35 ng/mL) of adapalene in the plasma samples from any patient. Excretion appears to be primarily by the biliary route.

INDICATIONS AND USAGE

DIFFERIN� Cream is indicated for the topical treatment of acne vulgaris.

NDC 00299-5910-45 UPC/GTIN No.3-02995-91045-7 Mfg.Part No.591045
RX ITEM-Differin 0.1% Gel 45Gm By Galder
NDC 00299-5910-45 UPC/GTIN No.3-02995-91045-7 Mfg.Part No.591045

BRAND: DIFFERIN NDC: 00299-5910-45,299591045 UPC: 3-02995-91045-7,302995910457 Galderma Labs
Differin 0.1% Gel 45Gm By Galderma Labs
BRAND: DIFFERIN NDC: 00299-5910-45,299591045 UPC: 3-02995-91045-7,302995910457 Galderma Labs

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ADAPALENE TOPICAL GEL (GR
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.