RX ITEM-Dibenzyline 10Mg Cap 100 By Concordia Pharma

DIBENZYLINE- phenoxybenzamine hydrochloride capsule
Concordia Pharmaceuticals Inc.

DESCRIPTION

Each Dibenzyline capsule, with red cap and body, is imprinted WPC 001 and 10 mg, and contains 10 mg of Phenoxybenzamine Hydrochloride USP. Inactive ingredients consist of D&C Red No. 33, FD&C Red No. 3, FD&C Yellow No. 6, Gelatin NF, and Lactose NF.

Dibenzyline is N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride:

structure
(click image for full-size original)


Phenoxybenzamine hydrochloride is a colorless, crystalline powder with a molecular weight of 340.3, which melts between 136� and 141�C. It is soluble in water, alcohol and chloroform; insoluble in ether.

CLINICAL PHARMACOLOGY

Dibenzyline (phenoxybenzamine hydrochloride) is a long-acting, adrenergic, alpha -receptor-blocking agent, which can produce and maintain �chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system.

Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.1

The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to 4 days, and the effects of daily administration are cumulative for nearly a week.1

INDICATION AND USAGE

Dibenzyline is indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta -blocking agent concomitantly.

RX ITEM-Dibenzyline 10Mg Cap 100 By Conc
NDC 65197-0001-01 UPC/GTIN No.3-65197-00101-9 Mfg.Part No.101

Dibenzyline 10Mg Cap 100 By Concordia Ph
BRAND: DIBENZYLINE NDC: 65197-0001-01,65197000101 UPC: 3-65197-00101-9,365197001019 Concordia Pharmaceuticals Inc

PHENOXYBENZAMINE HCL ORAL
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