RX ITEM-Desmopressin 4Mcg/Ml Vial 10Ml By Ferring Pharm

DESMOPRESSIN ACETATE- desmopressin acetate injection, solution
Hospira, Inc.


NOVAPLUS� Rx only

DESCRIPTION

Desmopressin Acetate Injection, USP 4 mcg/mL is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is chemically defined as follows:

Mol. Wt. 1183.31

Molecular Formula: C46 H64 N14 O12 S2 � C2 H4 O2 � 3H2 O

structural formula desmopressin acetate injection
(click image for full-size original)


1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.

Desmopressin Acetate Injection, USP 4 mcg/mL is provided as a sterile, aqueous solution for intravenous or subcutaneous use. Each mL contains desmopressin acetate, 4 mcg (equivalent to 0.004 mg of desmopressin) and sodium chloride, 9 mg. May contain hydrochloric acid for pH adjustment. The pH range is 3.5 to 6.0.

CLINICAL PHARMACOLOGY

Desmopressin Acetate Injection 4 mcg/mL contains as active substance, desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. One mL (4 mcg) of desmopressin acetate solution has an antidiuretic activity of about 16 IU; 1 mcg of desmopressin acetate is equivalent to 4 IU.

Desmopressin acetate has been shown to be more potent than arginine vasopressin in increasing plasma levels of factor VIII activity in patients with hemophilia and von Willebrand�s disease Type I.

Dose-response studies were performed in healthy persons, using doses of 0.1 to 0.4 mcg/kg body weight, infused over a 10-minute period. Maximal dose response occurred at 0.3 to 0.4 mcg/kg. The response to desmopressin acetate of factor VIII activity and plasminogen activator is dose-related, with maximal plasma levels of 300 to 400 percent of initial concentrations obtained after infusion of 0.4 mcg/kg body weight. The increase is rapid and evident within 30 minutes, reaching a maximum at a point ranging from 90 minutes to two hours. The factor VIII related antigen and ristocetin cofactor activity were also increased to a smaller degree, but still are dose-dependent.

RX ITEM-Desmopressin 4Mcg/Ml Vial 10Ml B
NDC 55566-5040-01 UPC/GTIN No.3-55566-50401-2 Mfg.Part No.504001

Desmopressin 4Mcg/Ml Vial 10Ml By Ferrin
BRAND: DESMOPRESSIN NDC: 55566-5040-01,55566504001 UPC: 3-55566-50401-2,355566504012 Ferring Pharma Inc.

DESMOPRESSIN ACETATE INJE
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.