DERMAZENE- hydrocortisone and iodoquinol cream
Stratus Pharamceuticals, Inc
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
Rx only
DESCRIPTION
Each gram of Dermazene� Cream 1% contains 10 mg of hydrocortisone and 10 mg of iodoquinol in a cream base of purified water, propylene glycol, cerasynt SE, amerchol L101, isopropyl palmitate, cetyl alcohol, arlacel 60, myrj 52, tween 60, sorbic acid, methyl paraben and propyl paraben.
Chemically, hydrocortisone is [Pregn-4-ene-3,20-dione, 11, 17, 21-trihydroxy-(11?)-] with the molecular formula (C21 H30 O5 ) and is represented by the following structural formula:
Chemical Structure
and iodoquinol, 5,7-diiodo-8-quinolinol (C9 H5 I2 NO) is represented by the following structure:
Chemical Structure
Hydrocortisone is an anti-inflammatory and antipruritic agent, while iodoquinol is an antifungal and antibacterial agent.
CLINICAL PHARMACOLOGY
Hydrocortisone has anti-inflammatory, antipruritic and vasoconstrictor properties. The mechanism of anti-inflammatory activity is unclear. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.