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RX ITEM-Depo Estradiol 5Mg/Ml Vial 5Ml By Pfizer Pharma

NDC 00009-0271-01 UPC/GTIN No.3-00090-27101-5 Mfg.Part No.1444BRAND: DEPO-ESTRADIOL NDC: 00009-0271-01,9027101 UPC: 3-00090-27101-5,300090271015 Pfizer PharmaceuticalOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Depo Estradiol 5Mg/Ml Vial 5Ml By Pfizer Pharma

$115.45$99.98

item No.:RX288647 NDC No.9027101 UPC No.:300090271015 NDC No. 00009-0271-01 UPC/GTIN No. 3-00090-27101-5 MPN 1444 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx288647 Depo Estradiol 5mg/ml Vial 5ml by Pfizer Pharm Item No. 3288647 NDC No. 00009027101 UPC No. 300090271015 Other Name Estradiol Cy

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DEPO-ESTRADIOL- estradiol cypionate injection
Pharmacia and Upjohn Company

WARNINGS

ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER
Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures including endometrial sampling, when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is currently no evidence that the use of “natural” estrogens results in a different endometrial risk profile than “synthetic” estrogens at equivalent estrogen doses. (See WARNINGS, malignant neoplasms, Endometrial cancer.)

CARDIOVASCULAR AND OTHER RISKS


Estrogens with and without progestins should not be used for the prevention of cardiovascular disease. (See WARNINGS, Cardiovascular disorders.)

The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical Studies.)

The Women’s Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen-alone therapy. (See CLINICAL PHARMACOLOGY, Clinical Studies.)

Other doses of conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DESCRIPTION

DEPO-Estradiol Injection contains estradiol cypionate for intramuscular use. Each mL contains:

5 mg/mL—5 mg estradiol cypionate, 5.4 mg chlorobutanol anhydrous (chloral derivative) added as preservative; in 913 mg cottonseed oil.

Warning: Chlorobutanol may be habit forming. The structural formula is represented below:

Chemical Structure
(click image for full-size original)
DEPO-Estradiol contains an oil soluble ester of estradiol 17?. The chemical name for estradiol cypionate is estradiol 17-cyclopentanepropionate.

CLINICAL PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.

The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women.

Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue.

Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.

NDC 00009-0271-01 UPC/GTIN No.3-00090-27101-5 Mfg.Part No.1444
RX ITEM-Depo Estradiol 5Mg/Ml Vial 5Ml B
NDC 00009-0271-01 UPC/GTIN No.3-00090-27101-5 Mfg.Part No.1444

BRAND: DEPO-ESTRADIOL NDC: 00009-0271-01,9027101 UPC: 3-00090-27101-5,300090271015 Pfizer Pharmaceutical
Depo Estradiol 5Mg/Ml Vial 5Ml By Pfizer
BRAND: DEPO-ESTRADIOL NDC: 00009-0271-01,9027101 UPC: 3-00090-27101-5,300090271015 Pfizer Pharmaceutical

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ESTRADIOL CYPIONATE INTRA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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