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Rx Item-Depen Titrata 250Mg Tab 100 By Meda Pharma

NDC 00037-4401-01 UPC/GTIN No.3-00374-40101-5 Mfg.Part No.440101BRAND: DEPEN NDC: 00037-4401-01,37440101 UPC: 3-00374-40101-5,300374401015 Meda PharmaceuticalsOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Depen Titrata 250Mg Tab 100 By Meda Pharma

$7804.69$7433.04

Item No.:RX270017 NDC No.37440101 UPC No.:300374401015 NDC No. 00037-4401-01 UPC/GTIN No. 3-00374-40101-5 MPN 440101 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx270017 Depen Titrata 250mg Tab 100 by Meda Pharma Item No. 3270017 NDC No. 00037440101 UPC No. 300374401015 Other Name Penicillamine

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DEPEN- penicillamine tablet
Meda Pharmaceuticals Inc.


Physicians planning to use penicillamine should thoroughly familiarize themselves with its toxicity, special dosage considerations, and therapeutic benefits. Penicillamine should never be used casually. Each patient should remain constantly under the close supervision of the physician. Patients should be warned to report promptly any symptoms suggesting toxicity.


DESCRIPTION � Penicillamine is 3-mercapto-D-valine, a disease modifying antirheumatic drug. It is a white or practically white, crystalline powder, freely soluble in water, slightly soluble in alcohol, and insoluble in ether, acetone, benzene, and carbon tetrachloride. Although its configuration is D, it is levorotatory as usually measured:

Drug Configuration
(click image for full-size original)


The empirical formula is C5 H11 NO2 S, giving it a molecular weight of 149.21. The structural formula is:

Structural Formula
It reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic acid.

Depen� (penicillamine tablets, USP) Titratable Tablets for oral administration contain 250 mg of penicillamine.

Other ingredients (inactive): edetate disodium, hypromellose, lactose, magnesium stearate, magnesium trisilicate, polyethylene glycol, povidone, simethicone emulsion, starch, and stearic acid.


CLINICAL PHARMACOLOGY � Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson�s disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine, it would appear that one gram of penicillamine should be followed by the excretion of about 200 milligrams of copper; however, the actual amount excreted is about one percent of this.

Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between penicillamine and cystine, resulting in formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily.

Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed.

The mechanism of action of penicillamine in rheumatoid arthritis is unknown, although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants, which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.

In vitro , penicillamine dissociates macroglobulins (rheumatoid factor) although the relationship of the activity to its effect in rheumatoid arthritis is not known.

In rheumatoid arthritis, the onset of therapeutic response to DEPEN may not be seen for two or three months. In those patients who respond, however, the first evidence of suppression of symptoms such as pain, tenderness, and swelling usually is generally apparent within three months. The optimum duration of therapy has not been determined. If remissions occur, they may last from months to years but usually require continued treatment (see DOSAGE AND ADMINISTRATION).

In all patients receiving penicillamine, it is important that DEPEN be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food or milk. This permits maximum absorption and reduces the likelihood of inactivation by metal binding in the gastrointestinal tract.

Methodology for determining the bioavailability of penicillamine is not available; however, penicillamine is known to be a very soluble substance.


INDICATIONS � DEPEN is indicated in the treatment of Wilson�s disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. Available evidence suggests that DEPEN is not of value in ankylosing spondylitis.

NDC 00037-4401-01 UPC/GTIN No.3-00374-40101-5 Mfg.Part No.440101
RX ITEM-Depen Titrata 250Mg Tab 100 By M
NDC 00037-4401-01 UPC/GTIN No.3-00374-40101-5 Mfg.Part No.440101

BRAND: DEPEN NDC: 00037-4401-01,37440101 UPC: 3-00374-40101-5,300374401015 Meda Pharmaceuticals
Depen Titrata 250Mg Tab 100 By Meda Phar
BRAND: DEPEN NDC: 00037-4401-01,37440101 UPC: 3-00374-40101-5,300374401015 Meda Pharmaceuticals

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
PENICILLAMINE ORAL TABLET
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.