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Rx Item-Demeclocycline 150Mg Tab 100 By Amneal Pharma

NDC 65162-0554-10 UPC/GTIN No.3-65162-55410-6 Mfg.Part No.55410BRAND: DEMECLOCYCLIN NDC: 65162-0554-10,65162055410 UPC: 3-65162-55410-6,365162554106 Amneal Pharma Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Demeclocycline 150Mg Tab 100 By Amneal Pharma

$940.12$634.29

Item No.:RX955237/H, Item No. RX955237, 955237, NDC No.: 65162-0554-10, 65162-554-10, 6516255410, 65162055410, 0554-10, 055410 UPC No. 3-65162-55410-6, 365162-554106, 365162554106, Rx Item-Demeclocycline 150Mg Tab 100 By Amneal Pharma Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Anti-Infectives Tetracycline AntibioticsDrug Class: 8122400 Tetracycline Antibiotics

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DEMECLOCYCLINE HYDROCHLORIDE- demeclocycline hydrochloride tablet, film coated
VersaPharm Incorporated

For Oral Use

Rx Only

To reduce the development of drug-resistant bacteria and maintain the effectiveness of demeclocycline hydrochloride tablets and other antibacterial drugs, demeclocycline hydrochloride tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DESCRIPTION

Demeclocycline hydrochloride is an antibiotic isolated from a mutant strain of Streptomyces aureofaciens. Chemically it is 7-Chloro-4-(dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy-1, 11-dioxo-2-naphthacenecarboxamide monohydrochloride.



Its structural formula is:

Chemical Structure
(click image for full-size original)
Demeclocycline Hydrochloride film coated tablet for oral administration, contains 150 mg or 300 mg of demeclocycline hydrochloride and the following inactive ingredients: Croscarmellose sodium, colloidal silicon dioxide, ethylcellulose, microcrystalline cellulose, magnesium stearate, FD&C Red #40, FD&C Yellow #6, hypromellose, polydextrose, polyethylene glycol, titanium dioxide, and triacetin.

CLINICAL PHARMACOLOGY

Pharmacokinetics
The absorption of demeclocycline is slower than that of tetracycline. The time to reach the peak concentration is about 4 hours. After a 150 mg oral dose of demeclocycline tablet, the mean concentrations at 1 hour and 3 hours are 0.46 and 1.22 ?g/mL (n=6), respectively. The serum half-life ranges between 10 and 16 hours. When demeclocycline hydrochloride is given concomitantly with some dairy products, or antacids containing aluminum, calcium, or magnesium, the extent of absorption is reduced by more than 50%. Demeclocycline hydrochloride penetrates well into various body fluids and tissues. The percent of demeclocycline hydrochloride bound to plasma protein is about 40% using a dialysis equilibrium method and 90% using an ultra-filtration method. Demeclocycline hydrochloride like other tetracyclines, is concentrated in the liver and excreted into the bile where it is found in much higher concentrations than in the blood. The rate of demeclocycline hydrochloride renal clearance (35 mL/min/1.73 m2) is less than half that of tetracycline. Following a single 150 mg dose of demeclocycline hydrochloride in normal volunteers, 44% (n = 8) was excreted in urine and 13% and 46%, respectively, were excreted in feces in two patients within 96 hours as active drug.

Microbiology
Mechanism of Action

The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. The tetracyclines, including demeclocycline, have a similar antimicrobial spectrum of activity against a wide range of gram-negative and gram-positive organisms.

Mechanism(s) of Resistance

Resistance to tetracyclines may be mediated by efflux, alteration in the target site of tetracycline, enzymatic inactivation, and decreased bacterial permeability to the tetracycline or a combination of these mechanisms.

NDC 65162-0554-10 UPC/GTIN No.3-65162-55410-6 Mfg.Part No.55410
RX ITEM-Demeclocycline 150Mg Tab 100 By
NDC 65162-0554-10 UPC/GTIN No.3-65162-55410-6 Mfg.Part No.55410

BRAND: DEMECLOCYCLIN NDC: 65162-0554-10,65162055410 UPC: 3-65162-55410-6,365162554106 Amneal Pharma
Demeclocycline 150Mg Tab 100 By Amneal P
BRAND: DEMECLOCYCLIN NDC: 65162-0554-10,65162055410 UPC: 3-65162-55410-6,365162554106 Amneal Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
DEMECLOCYCLINE HCL ORAL T
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.