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Rx Item-Delestrogen 20Mg/Ml Vial 5Ml By JHP Pharma

NDC 42023-0111-01 UPC/GTIN No.3-42023-11101-2 Mfg.Part No.11101 Brand Name	DELESTROGEN 20MG/ML Rx itemBrand Name Product
Generic Name	DELESTROGEN 20MG/ML
Product Description	MDV (IJ)
NDC Code	42023BRAND: DELESTROGEN NDC: 42023-0111-01,42023011101 UPC: 3-42023-11101-2,342023111012 JHP Pharma Brand Name	DELESTROGEN 20MG/ML Rx itemBrand Name Product
Generic Name	DELESTROGEN 20MG/ML
Product DescrOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Delestrogen 20Mg/Ml Vial 5Ml By JHP Pharma

$224.48$203.97

Item No.:RX058271 NDC No.42023011101 UPC No.:342023111012 NDC No. 42023-0111-01 UPC/GTIN No. 3-42023-11101-2 MPN 11101 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx058271 Delestrogen 20mg/ml Vial 5ml by JHP Pharma Item No. 3058271 NDC No. 42023011101 UPC No. 342023111012 Other Name Estradiol V

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DELESTROGEN- estradiol valerate injection
JHP Pharmaceuticals LLC

ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER
Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses. (See WARNINGS, Malignant neoplasms, Endometrial cancer.)

CARDIOVASCULAR AND OTHER RISKS


Estrogens and progestins should not be used for the prevention of cardiovascular disease. (See WARNINGS, Cardiovascular disorders.)

The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See CLININAL PHARMACOLOGY, Clinical Studies.)

The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen alone therapy. (See CLINICAL PHARMACOLOGY, Clinical Studies.)

Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DESCRIPTION

DELESTROGEN� (estradiol valerate injection, USP) contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to pale yellow. Formulations (per mL): 10 mg estradiol valerate in a vehicle containing 5 mg chlorobutanol (chloral derivative/preservative) and sesame oil; 20 mg estradiol valerate in a vehicle containing 224 mg benzyl benzoate, 20 mg benzyl alcohol (preservative), and castor oil; 40 mg estradiol valerate in a vehicle containing 447 mg benzyl benzoate, 20 mg benzyl alcohol, and castor oil.

Estradiol valerate is designated chemically as estra-1,3,5(10)-triene-3, 17-diol(17?)-, 17-pentanoate. Graphic formula:

Chemical Structure
(click image for full-size original)
C23 H32 O3 MW 356.50
CLINICAL PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.

The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women.

Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue.

Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.

NDC 42023-0111-01 UPC/GTIN No.3-42023-11101-2 Mfg.Part No.11101 Brand Name	DELESTROGEN 20MG/ML Rx itemBrand Name Product
Generic Name	DELESTROGEN 20MG/ML
Product Description	MDV (IJ)
NDC Code	42023
RX ITEM-Delestrogen 20Mg/Ml Vial 5Ml By
NDC 42023-0111-01 UPC/GTIN No.3-42023-11101-2 Mfg.Part No.11101 Brand Name DELESTROGEN 20MG/ML Rx itemBrand Name Product Generic Name DELESTROGEN 20MG/ML Product Description MDV (IJ) NDC Code 42023

BRAND: DELESTROGEN NDC: 42023-0111-01,42023011101 UPC: 3-42023-11101-2,342023111012 JHP Pharma Brand Name	DELESTROGEN 20MG/ML Rx itemBrand Name Product
Generic Name	DELESTROGEN 20MG/ML
Product Descr
42023011101
BRAND: DELESTROGEN NDC: 42023-0111-01,42023011101 UPC: 3-42023-11101-2,342023111012 JHP Pharma Brand Name DELESTROGEN 20MG/ML Rx itemBrand Name Product Generic Name DELESTROGEN 20MG/ML Product Descr

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ESTRADIOL VALERATE INTRAM
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.