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RX ITEM-DDAVP Nasal 10 Spray Spray 5Ml By Ferring Pharm

NDC 00075-2452-01 UPC/GTIN No.3-00752-45201-1 Mfg.Part No.245201BRAND: DDAVP NDC: 00075-2452-01,75245201 UPC: 3-00752-45201-1,300752452011 Ferring Pharma Inc.Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-DDAVP Nasal 10 Spray Spray 5Ml By Ferring Pharm

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item No.:RX269878 NDC No.75245201 UPC No.:300752452011 NDC No. 00075-2452-01 UPC/GTIN No. 3-00752-45201-1 MPN 245201 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx269878 DDAVP Nasal 10/Spray Spy 5ml by Ferring Pharm Item No. 3269878 NDC No. 00075245201 UPC No. 300752452011 Other Name Desmopress

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DDAVP- desmopressin acetate spray
Ferring Pharmaceuticals Inc.

Rx only

DESCRIPTION

DDAVP� Nasal Spray (desmopressin acetate) is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is chemically defined as follows:

Mol. wt. 1183.34

Empirical formula: C46 H64 N14 O12 S2 ?C2 H4 O2 ?3H2 O

Chemical Structure
(click image for full-size original)


1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.

DDAVP Nasal Spray is provided as an aqueous solution for intranasal use.

Each mL contains:
Desmopressin acetate 0.1 mg
Sodium Chloride 7.5 mg
Citric acid monohydrate 1.7 mg
Disodium phosphate dihydrate 3.0 mg
Benzalkonium chloride solution (50%) 0.2 mg
The DDAVP Nasal Spray compression pump delivers 0.1 mL (10 mcg) of DDAVP (desmopressin acetate) per spray.

CLINICAL PHARMACOLOGY

DDAVP contains as active substance desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. One mL (0.1 mg) of intranasal DDAVP has an antidiuretic activity of about 400 International Units (IU); 10 mcg of desmopressin acetate is equivalent to 40 IU.

The biphasic half-lives for intranasal DDAVP were 7.8 and 75.5 minutes for the fast and slow phases, compared with 2.5 and 14.5 minutes for lysine vasopressin, another form of the hormone used in this condition. As a result, intranasal DDAVP provides a prompt onset of antidiuretic action with a long duration after each administration.
The change in structure of arginine vasopressin to DDAVP has resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antidiuretic activity, so that clinically effective antidiuretic doses are usually below threshold levels for effects on vascular or visceral smooth muscle.
DDAVP administered intranasally has an antidiuretic effect about one-tenth that of an equivalent dose administered by injection.
Human Pharmacokinetics
DDAVP is mainly excreted in the urine. A pharmacokinetic study conducted in healthy volunteers and patients with mild, moderate, and severe renal impairment (n=24, 6 subjects in each group) receiving single dose desmopressin acetate (2 mcg) injection demonstrated a difference in DDAVP terminal half-life. Terminal half-life significantly increased from 3 hours in normal healthy patients to 9 hours in patients with severe renal impairment. (See CONTRAINDICATIONS.)

INDICATIONS AND USAGE

Central Cranial Diabetes Insipidus
DDAVP Nasal Spray is indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. It is ineffective for the treatment of nephrogenic diabetes insipidus.

The use of DDAVP Nasal Spray in patients with an established diagnosis will result in a reduction in urinary output with increase in urine osmolality and a decrease in plasma osmolality. This will allow the resumption of a more normal life-style with a decrease in urinary frequency and nocturia.

There are reports of an occasional change in response with time, usually greater than 6 months. Some patients may show a decreased responsiveness, others a shortened duration of effect. There is no evidence this effect is due to the development of binding antibodies but may be due to a local inactivation of the peptide.

Patients are selected for therapy by establishing the diagnosis by means of the water deprivation test, the hypertonic saline infusion test, and/or the response to antidiuretic hormone. Continued response to intranasal DDAVP can be monitored by urine volume and osmolality.

DDAVP is also available as a solution for injection when the intranasal route may be compromised. These situations include nasal congestion and blockage, nasal discharge, atrophy of nasal mucosa, and severe atrophic rhinitis. Intranasal delivery may also be inappropriate where there is an impaired level of consciousness. In addition, cranial surgical procedures, such as transsphenoidal hypophysectomy create situations where an alternative route of administration is needed as in cases of nasal packing or recovery from surgery.

NDC 00075-2452-01 UPC/GTIN No.3-00752-45201-1 Mfg.Part No.245201
RX ITEM-DDAVP Nasal 10 Spray Spray 5Ml B
NDC 00075-2452-01 UPC/GTIN No.3-00752-45201-1 Mfg.Part No.245201

BRAND: DDAVP NDC: 00075-2452-01,75245201 UPC: 3-00752-45201-1,300752452011 Ferring Pharma Inc.
DDAVP Nasal 10 Spray Spray 5Ml By Ferrin
BRAND: DDAVP NDC: 00075-2452-01,75245201 UPC: 3-00752-45201-1,300752452011 Ferring Pharma Inc.

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
DESMOPRESSIN (NONREFRIGER
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.