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RX ITEM-Cosopt Preservative Free 2% 0.5% Dpt 60 By Akorn Pharma

NDC 00006-3629-60 UPC/GTIN No.3-00063-62960-7 Mfg.Part No.362960BRAND: COSOPT NDC: 00006-3629-60,6362960 UPC: 3-00063-62960-7,300063629607 Akorn IncOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Cosopt Preservative Free 2% 0.5% Dpt 60 By Akorn Pharma

$0.00

item No.:RX178386 NDC No.6362960 UPC No.:300063629607 NDC No. 00006-3629-60 UPC/GTIN No. 3-00063-62960-7 MPN 362960 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx178386 Cosopt Preservative Free 2%/0.5% Dpt 60 by Akorn Pharma Item No. 3178386 NDC No. 00006362960 UPC No. 300063629607 Other Name D

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COSOPT- dorzolamide hydrochloride and timolol maleate solution
Merck Sharp & Dohme Corp.

DESCRIPTION

COSOPT� (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.

Dorzolamide hydrochloride is described chemically as: (4S- trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H -thieno[2,3-b ]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is:



[?] 25�C (C=1, water) = ~ -17�.

405 nm

Its empirical formula is C10 H16 N2 O4 S3 �HCl and its structural formula is:

chemical structure for dorzolamide hydrochloride
Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

Timolol maleate is described chemically as: (-)-1-(tert -butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in its structure and is provided as the levo-isomer. The optical rotation of timolol maleate is:

[?] 25�C in 1N HCl (C = 5) = -12.2� (-11.7� to -12.5�).

405 nm

Its molecular formula is C13 H24 N4 O3 S�C4 H4 O4 and its structural formula is:

chemical structure for timolol maleate
(click image for full-size original)
Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol. Timolol maleate is stable at room temperature.

COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.

NDC 00006-3629-60 UPC/GTIN No.3-00063-62960-7 Mfg.Part No.362960
RX ITEM-Cosopt Preservative Free 2% 0.5%
NDC 00006-3629-60 UPC/GTIN No.3-00063-62960-7 Mfg.Part No.362960

BRAND: COSOPT NDC: 00006-3629-60,6362960 UPC: 3-00063-62960-7,300063629607 Akorn Inc
Cosopt Preservative Free 2% 0.5% Dpt 60
BRAND: COSOPT NDC: 00006-3629-60,6362960 UPC: 3-00063-62960-7,300063629607 Akorn Inc

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
DORZOLAMIDE/TIMOLOL/PF OP
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.