Rx Item-Corlopam 10Mg/Ml Amp 2Ml By Hospira Worldwide

CORLOPAM- fenoldopam mesylate injection, solution
Hospira, Inc.

1 INDICATIONS AND USAGE

1.1 Adult Patients
Fenoldopam is indicated for in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. Transition to oral therapy with another agent can begin at any time after blood pressure is stable during fenoldopam infusion.

1.2 Pediatric Patients


Fenoldopam is indicated for in-hospital, short-term (up to 4 hours) reduction in blood pressure [see Clinical Pharmacology (12.2) ].

2 DOSAGE AND ADMINISTRATION

2.1 Recommended Dosage
Adult Patients

Initiate dosing at 0.01 to 0.3 mcg/kg/min as a continuous intravenous infusion. Dosing may be increased in increments of 0.05 to 0.1 mcg/kg/minute every 15 minutes or longer, until target blood pressure is reached [see Clinical Pharmacology (12.2) ]; the maximal infusion rate reported in clinical studies was 1.6 mcg/kg/minute. Doses lower than 0.1 mcg/kg/min and slow up-titration have been associated with less reflex tachycardia. Maintenance infusions may be continued for up to 48 hours.

Oral antihypertensive agents can be added during fenoldopam infusion or after discontinuation.

Pediatric Patients

Initiate dosing at 0.2 mcg/kg/minute and titrate dose by 0.3 to 0.5 mcg/kg/min every 20-30 minutes to a maximum dose of 0.8 mcg/kg/minute. Higher doses generally produced no further decreases in MAP but did worsen tachycardia.

RX ITEM-Corlopam 10Mg/Ml Amp 2Ml By Hosp
NDC 00409-2304-02 UPC/GTIN No.3-04092-30402-3 Mfg.Part No.230402

Corlopam 10Mg/Ml Amp 2Ml By Hospira Worl
BRAND: CORLOPAM NDC: 00409-2304-02,409230402 UPC: 3-04092-30402-3,304092304023 Hospira Worldwide Inc.

FENOLDOPAM MESYLATE INTRA
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