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Rx Item-Clotrimazole 1% Cream 45Gm By Taro Pharma

NDC 51672-1275-06 UPC/GTIN No.3-51672-12756-5 Mfg.Part No.127506BRAND: CLOTRIMAZOLE NDC: 51672-1275-06,51672127506 UPC: 3-51672-12756-5,351672127565 Taro PharmaceuticalsOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Clotrimazole 1% Cream 45Gm By Taro Pharma

$48.95$13.39

Item No.:RX658872/a, Item No. RX658872, 658872, NDC No.: 51672-1275-06, 51672-275-06, 5167227506, 51672127506, 1275-06, 127506 UPC No. 3-51672-12756-5, 351672-127565, 351672127565, Rx Item-Clotrimazole 1% Cream 45Gm By Taro Pharma Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Anti-Infectives-Antifungals-Azoles TopicalDrug Class: 84040808 Azoles (Skin And Mucous Membrane)

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CLOTRIMAZOLE- clotrimazole solution
Teva Pharmaceuticals USA, Inc.

DESCRIPTION

Clotrimazole, USP is a synthetic antifungal agent having the chemical name [1 (o -Chloro-?,?-diphenylbenzyl)imidazole]. It has the following structural formula:

structural formula for clotrimazole
C22 H17 ClN2 M.W. 344.84

Clotrimazole is an odorless, white crystalline substance. It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycol 400, ethanol and chloroform.



Each mL of clotrimazole topical solution contains 10 mg clotrimazole, USP in a nonaqueous vehicle of polyethylene glycol 400.

CLINICAL PHARMACOLOGY

Clotrimazole is a broad spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms.

In vitro , clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophytonrubrum , Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis , and Candida species, including Candida albicans.

In general, the in vitro activity of clotrimazole corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes (Trichophyton, Microsporum, and Epidermophyton), and to that of the polyenes (amphotericin B and nystatin) against budding fungi (Candida). Using an in vivo (mouse) and an in vitro (mouse kidney homogenate) testing system, clotrimazole and miconazole were equally effective in preventing the growth of the pseudomycelia and mycelia of Candida albicans.

Strains of fungi having a natural resistance to clotrimazole are rare. Only a single isolate of Candida guilliermondi has been reported to have primary resistance to clotrimazole.

No single step or multiple step resistance to clotrimazole has developed during successive passages of Candida albicans and Trichophyton mentagrophytes. No appreciable change in sensitivity was detected after successive passages of isolates of C. albicans , C. krusei , or C. pseudotropicalis in liquid or solid media containing clotrimazole. Also, resistance could not be developed in chemically induced mutant strains of polyene resistant isolates of C. albicans. Slight, reversible resistance was noted in three isolates of C. albicans tested by one investigator. There is a single report that records the clinical emergence of a C. albicans strain with considerable resistance to flucytosine and miconazole, and with cross resistance to clotrimazole; the strain remained sensitive to nystatin and amphotericin B.

In studies of the mechanism of action, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Both these events began rapidly and extensively after addition of the drug.

Clotrimazole appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites. Following topical and vaginal administration, however, clotrimazole appears to be minimally absorbed.

Six hours after the application of radioactive clotrimazole 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of clotrimazole varied from 100 mcg/cm3 in the stratum corneum to 0.5 to 1 mcg/cm3 in the stratum reticulare, and 0.1 mcg/cm3 in the subcutis. No measurable amount of radioactivity (< 0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream. Only 0.5% or less of the applied radioactivity was excreted in the urine.

Following intravaginal administration of 100 mg 14 C-clotrimazole vaginal tablets to nine adult females, an average peak serum level, corresponding to only 0.03 mcg equivalents/mL of clotrimazole, was reached one to two days after application. After intravaginal administration of 5 g of 1% 14 C-clotrimazole vaginal cream, containing 50 mg active drug, to five subjects (one with candidal colpitis), serum levels corresponding to approximately 0.01 mcg equivalents/mL were reached between 8 and 24 hours after application.

INDICATIONS AND USAGE

Clotrimazole topical solution is indicated for the topical treatment of candidiasis due to Candida Albicans and tinea versicolor due to Malassezia furfur.

Clotrimazole is also available as a nonprescription item which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophytonrubrum , Trichophytonmentagrophytes , Epidermophytonfloccosum , and Microsporumcanis.

NDC 51672-1275-06 UPC/GTIN No.3-51672-12756-5 Mfg.Part No.127506
RX ITEM-Clotrimazole 1% Cream 45Gm By Ta
NDC 51672-1275-06 UPC/GTIN No.3-51672-12756-5 Mfg.Part No.127506

BRAND: CLOTRIMAZOLE NDC: 51672-1275-06,51672127506 UPC: 3-51672-12756-5,351672127565 Taro Pharmaceuticals
Clotrimazole 1% Cream 45Gm By Taro Pharm
BRAND: CLOTRIMAZOLE NDC: 51672-1275-06,51672127506 UPC: 3-51672-12756-5,351672127565 Taro Pharmaceuticals

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CLOTRIMAZOLE TOPICAL CREA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.