CLODAN- clobetasol propionate shampoo
Medimetriks Pharmaceuticals
Rx Only
FOR EXTERNAL USE ONLY.
NOT FOR OPHTHALMIC USE.
DESCRIPTION
Clodan� (clobetasol propionate) Shampoo, 0.05% contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. The chemical name of clobetasol propionate is 21-chloro-9-fluoro-11?, 17-dihydroxy-16?-methylpregna-1, 4-diene-3, 20-dione 17-propionate.
Chemical Structure
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Clobetasol propionate
Clobetasol propionate has a molecular weight of 466.97 (CAS Registry Number 25122-46-7). The molecular formula is C25 H32 CIFO5 . Clobetasol propionate is a white to practically white crystalline, odorless powder insoluble in water.
Each mL of Clodan� contains clobetasol propionate, 0.05%, in a shampoo base consisting of alcohol, coco-betaine, hydrochloric acid, polyquaternium-10, purified water, and sodium laureth sulfate.
CLINICAL PHARMACOLOGY
Like other topical corticosteroids, Clodan� has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2 .
