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Rx Item-Captopril-Hctz 50Mg/15mg Tab 100 By Mylan Pharma

Item No.: Rx989871 NDC No.378008401 UPC No.:303780084018 NDC No. 00378-0084-01 UPC/GTIN No. 3-03780-08401-8 MPN No. 8401 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.LabBRAND: CAPTOPRIL-HCT NDC: 00378-0084-01,378008401 UPC: 3-03780-08401-8,303780084018 Mylan PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Captopril-Hctz 50Mg/15mg Tab 100 By Mylan Pharma

$489.67$171.97

Item No.: Rx989871 NDC No.378008401 UPC No.:303780084018 NDC No. 00378-0084-01 UPC/GTIN No. 3-03780-08401-8 MPN No. 8401 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.Lab, Naturalist, Naturopath, NP, Optometrist, Pharmacist, PA, Physical Therapist, Podiatrist, Research Co., Uni., VA, Vet & Wholesalers In Scope Of their Practice Can Order Rx Item. Rx Item No. Rx989871 Captopril-Hctz 50Mg/15mg Tab 100 By Mylan Pharma Item No. 3989871 NDC No. 00378008401 UPC No. 303780

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CAPTOPRIL- captopril tablet
Mylan Pharmaceuticals Inc.

WARNING: FETAL TOXICITY


When pregnancy is detected, discontinue captopril tablets as soon as possible.

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity.
DESCRIPTION



Captopril is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II.

Captopril is designated chemically as 1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline (MW 217.29) and has the following structure:

Structural Formula
C9 H15 NO3 S
Captopril, USP is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate.

Each tablet for oral administration contains 12.5 mg, 25 mg, 50 mg or 100 mg of captopril and the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, crospovidone, microcrystalline cellulose and stearic acid.

CLINICAL PHARMACOLOGY

Mechanism of Action
The mechanism of action of captopril has not yet been fully elucidated. Its beneficial effects in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. However, there is no consistent correlation between renin levels and response to the drug. Renin, an enzyme synthesized by the kidneys, is released into the circulation where it acts on a plasma globulin substrate to produce angiotensin I, a relatively inactive decapeptide. Angiotensin I is then converted by angiotensin converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. Angiotensin II also stimulates aldosterone secretion from the adrenal cortex, thereby contributing to sodium and fluid retention.

Captopril prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE, a peptidyldipeptide carboxy hydrolase. This inhibition has been demonstrated in both healthy human subjects and in animals by showing that the elevation of blood pressure caused by exogenously administered angiotensin I was attenuated or abolished by captopril. In animal studies, captopril did not alter the pressor responses to a number of other agents, including angiotensin II and norepinephrine, indicating specificity of action.

ACE is identical to “bradykininase”, and captopril may also interfere with the degradation of the vasodepressor peptide, bradykinin. Increased concentrations of bradykinin or prostaglandin E2 may also have a role in the therapeutic effect of captopril.

Inhibition of ACE results in decreased plasma angiotensin II and increased plasma renin activity (PRA), the latter resulting from loss of negative feedback on renin release caused by reduction in angiotensin II. The reduction of angiotensin II leads to decreased aldosterone secretion, and, as a result, small increases in serum potassium may occur along with sodium and fluid loss. The antihypertensive effects persist for a longer period of time than does demonstrable inhibition of circulating ACE. It is not known whether the ACE present in vascular endothelium is inhibited longer than the ACE in circulating blood.

Item No.: Rx989871 NDC No.378008401 UPC No.:303780084018 NDC No. 00378-0084-01 UPC/GTIN No. 3-03780-08401-8 MPN No. 8401 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.Lab
RX ITEM-Captopril-HCTZ 50Mg/15Mg Tab 100
Item No.: Rx989871 NDC No.378008401 UPC No.:303780084018 NDC No. 00378-0084-01 UPC/GTIN No. 3-03780-08401-8 MPN No. 8401 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.Lab

BRAND: CAPTOPRIL-HCT NDC: 00378-0084-01,378008401 UPC: 3-03780-08401-8,303780084018 Mylan Pharma
Captopril-HCTZ 50Mg/15Mg Tab 100 By Myla
BRAND: CAPTOPRIL-HCT NDC: 00378-0084-01,378008401 UPC: 3-03780-08401-8,303780084018 Mylan Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CAPTOPRIL/HYDROCHLOROTHIA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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