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Cafergot 1mg 100mg Tab 100 by Sandoz Pharma

NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501Sandoz/RxThis Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).Sandoz/RxImage 4 of Cafergot 1mg 100mg Tab 100 by Sandoz Pharma

Cafergot 1mg 100mg Tab 100 by Sandoz Pharma

$1543.69$1389.99

NDC No. 00781-5405-01 UPC/GTIN No. 3-07815-40501-4 MPN 540501 Only Physician,Pharmacy or Licensed Facility can order this Rx Item No. Rx138646 Cafergot 1mg/100mg Tab 100 by Sandoz Pharma Item No. 3138646 NDC No. 00781540501 UPC No. 307815405014 Other Name ERgotamine Tartrate-Caffe Therapeutic Code 121604 Therapeutic Class Selective Alpha-1-Adrenergic Block.Agent Item Class Non Controlled Rx. Case Qnty: 48 Therapeutic Code 121604 Selective Alpha-1-Adrenergic Block.Agent Info ERgotamine Derivativ

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CAFERGOT- ergotamine tartrate and caffeine tablet, film coated
Sandoz Inc

Rx only

WARNING

Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of CAFERGOT® with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of CAFERGOT®, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated (see also CONTRAINDICATIONS and WARNINGS section).

DESCRIPTION



Each tablet for oral administration contains 1 mg ergotamine tartrate, USP, and 100 mg caffeine, USP.

ERGOTAMINE TARTRATE:

Ergotamine Tartrate Chemical Structure
(click image for full-size original)
Ergotaman-3?,6?,18-trione, 12?-hydroxy-2?-methyl-5?-(phenyl-methyl)-,(5? ?)-, [R-(R*,R*)]-2,3-dihydroxy-butanedioate (2:1) (salt).

CAFFEINE:

Caffeine Chemical Structure
1H -Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-.

Inactive ingredients include black iron oxide, compressible sugar, iron oxide red, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium starch glycolate, talc, titanium dioxide and yellow iron oxide.

CLINICAL PHARMACOLOGY

Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to hydrogenated ergotamine, the adrenergic blocking actions are less pronounced and vasoconstrictive actions are greater.

Caffeine, also a cranial vasoconstrictor, is added to further enhance the vasoconstrictive effect without the necessity of increasing ergotamine dosage.

Many migraine patients experience excessive nausea and vomiting during attacks, making it impossible for them to retain any oral medication. In such cases, therefore, the only practical means of medication is through the rectal route where medication may reach the cranial vessels directly, evading the splanchnic vasculature and the liver.

NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501
Cafergot 1mg 100mg Tab 100 by Sandoz Pha
NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501

Sandoz/Rx

Sandoz/Rx

This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).
ERGOTAMINE TARTRATE/CAFFE
This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).

Sandoz/Rx
Sandoz/Rx

Image 4 of Cafergot 1mg 100mg Tab 100 by Sandoz Pharma