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RX ITEM-Cafergot 1Mg/100Mg Tab 100 By Sandoz Pharma

NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501BRAND: CAFERGOT NDC: 00781-5405-01,781540501 UPC: 3-07815-40501-4,307815405014 Sandoz/RxOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Cafergot 1Mg/100Mg Tab 100 By Sandoz Pharma

$1543.69$1389.99

item No.:RX138646/H NDC No.781540501 UPC No.:307815405014 NDC No. 00781-5405-01 UPC/GTIN No. 3-07815-40501-4 MPN 540501 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx138646 Cafergot 1mg/100mg Tab 100 by Sandoz Pharma Item No. 3138646 NDC No. 00781540501 UPC No. 307815405014 Other Name ERgotamin

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CAFERGOT- ergotamine tartrate and caffeine tablet, film coated
Sandoz Inc

Rx only

WARNING

Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of CAFERGOT® with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of CAFERGOT®, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated (see also CONTRAINDICATIONS and WARNINGS section).

DESCRIPTION



Each tablet for oral administration contains 1 mg ergotamine tartrate, USP, and 100 mg caffeine, USP.

ERGOTAMINE TARTRATE:

Ergotamine Tartrate Chemical Structure
(click image for full-size original)
Ergotaman-3?,6?,18-trione, 12?-hydroxy-2?-methyl-5?-(phenyl-methyl)-,(5? ?)-, [R-(R*,R*)]-2,3-dihydroxy-butanedioate (2:1) (salt).

CAFFEINE:

Caffeine Chemical Structure
1H -Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-.

Inactive ingredients include black iron oxide, compressible sugar, iron oxide red, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium starch glycolate, talc, titanium dioxide and yellow iron oxide.

CLINICAL PHARMACOLOGY

Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to hydrogenated ergotamine, the adrenergic blocking actions are less pronounced and vasoconstrictive actions are greater.

Caffeine, also a cranial vasoconstrictor, is added to further enhance the vasoconstrictive effect without the necessity of increasing ergotamine dosage.

Many migraine patients experience excessive nausea and vomiting during attacks, making it impossible for them to retain any oral medication. In such cases, therefore, the only practical means of medication is through the rectal route where medication may reach the cranial vessels directly, evading the splanchnic vasculature and the liver.

NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501
RX ITEM-Cafergot 1Mg/100Mg Tab 100 By Sa
NDC 00781-5405-01 UPC/GTIN No.3-07815-40501-4 Mfg.Part No.540501

BRAND: CAFERGOT NDC: 00781-5405-01,781540501 UPC: 3-07815-40501-4,307815405014 Sandoz/Rx
Cafergot 1Mg/100Mg Tab 100 By Sandoz Pha
BRAND: CAFERGOT NDC: 00781-5405-01,781540501 UPC: 3-07815-40501-4,307815405014 Sandoz/Rx

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ERGOTAMINE TARTRATE/CAFFE
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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