Rx Item-Atropine Sulfate Lfs 0.1mg/ml Syg 10X10ml by Hospira Worldwide

Clinical Information
Gen. Code and Des.
4817 atropine sulfate INJECTION SYRINGE 0.1 MG/ML
GCN and Des.
18661 atropine sulfate INJECTION SYRINGE 0.1 MG/ML
Strength
1MG
Dose Form
SYRINGE (ML)
Product Category
RX Pharmaceuticals
Fine Line Class
850085008510 All Rx Products
DEA Class
NC
OMP Family

AHFS Class
12080800 ANTIMUSCARINICS/ANTISPASMODICS
Active Ingredients
1717 atropine sulfate 5908996

ATROPINE SULFATE atropine sulfate injection
Amphastar Pharmaceuticals, Inc.

DESCRIPTION
Atropine is chemically ? H, ? ? Tropan-3 ?-ol (?) -tropate (ester
Atropine rarely occurs as such in any of the plants and has been prepared by synthesis. It is usually employed in the form of atropine sulfate (the sulfate [2:1] monohydrate salt of atropine), which has much greater solubility in water.
Atropine Sulfate Injection, USP, is sterile aqueous solution of atropine sulfate. Each mL contains atropine sulfate, 0.1 mg; sodium chloride, 8.8 mg, for isotonicity; citric acid, 0.63 mg, and sodium citrate, 0.29 mg, as buffers. May contain additional citric acid and/or sodium citrate for pH adjustment (3.0-6.5). The air above the liquid in the container has been displaced by nitrogen gas.
CLINICAL PHARMACOLOGY
Atropine inhibits the muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites including smooth muscle, secretory glands and CNS sites. Large doses may block nicotinic receptors at the autonomic ganglia and at the neuromuscular junction.
Atropine Sulfate Indications and USAge
Atropine Sulfate Injection, USP, may be given parenterally as pre-anesthetic medication in surgical patients to reduce salivation and bronchial secretions. It may also be used to suppress vagal activity associated with the use of halogenated hydrocarbons during inhalation anesthesia and reflex excitation arising from mechanical stimulation during surgery.
The antispasmodic action of atropine is useful in pylorospasm and other spastic conditions of the gastrointestinal tract. For ureteral and biliary colic, atropine concomitantly with morphine may be indicated.
Atropine relaxes the upper GI tract and colon during hypotonic radiography.
In poisoning by the organic phosphate cholinesterase inhibitors found in certain insecticides and by chemical warfare nerve gases, large doses of atropine relieve the muscarine-like symptoms and some of the central nervous system manifestations. It is also used as an antidote for mushroom poisoning due to muscarine in certain species such as Amanita muscaria.
CONTRAINDICATIONS
Atropine Sulfate is contraindicated in patients with history of hypersensitivity to this drug.
Ocular: Narrow-angle glaucoma; adhesions (synechiae) between the iris and lens of the eye.
Cardiovascular: Tachycardia; unstable cardiovascular status in acute hemorrhage.
GI: Obstructive disease (e.g., achalasia, pyloroduodenal stenosis, or pyloric obstruction, cardiospasm, etc.); paralytic ileus; intestinal atony of the elderly or debilitated patient; severe ulcerative colitis; toxic megacolon complicating ulcerative colitis; hepatic disease.
GU: Obstructive uropathy (e.g., bladder neck obstruction due to prostatic hypertrophy); renal disease.
Musculoskeletal: Myasthenia gravis.
WARNINGS
Heat prostration can occur with anticholinergic drug use (fever and heat stroke due to decreased sweating) in the presence of high environmental temperature.
Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Treatment of diarrhea with these drugs is inappropriate and possibly harmful.
USAge in the elderly: Elderly patients may react with excitement, agitation, drowsiness and other untoward manifestations to even small doses of anticholinergic drugs.
USAge in gastric ulcer may produce delay in gastric emptying time and may complicate such therapy (antral stasis).

Atropine Sulfate Lfs 0.1mg/ml Syg 10X10m
NDC No.00409-4911-34 UPC/GTIN No.3-04094-91134-2 MPN 491134 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapi

Atropine Sulfate Lfs 0.1mg/ml
Hospira Worldwide Inc. Atropine Sulfate Lfs 0.1mg/ml Syg 10X10ml by Hospira Worldwide

ATROPINE SULFATE INJECTIO
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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