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Rx Item-Atacand 32mg Tab 90 by ANI Pharma

NDC No.NEW 62559-0643-90 62559-643-90 OLD 00186-0032-54 UPC/GTIN No.3-62559-64390-0 MPN 3900  Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,OptometrAstra Zeneca PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Atacand 32mg Tab 90 by ANI Pharma

$1346.99$1191.99

NDC No.NEW 62559-0643-90 62559-643-90 OLD 00186-0032-54 UPC/GTIN No.3-62559-64390-0 MPN 3900 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No.Rx789214 Atacand 32mg Tab 90 by ANI Pharma Item No.3789214 NDC No.NEW 62559064390 6255964390 OLD 00186003254 UPC No.NEEW 362559-643900 362559643900 OLD 30186

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ATACAND- candesartan cilexetil tablet
ANI PHARMA

DESCRIPTION
ATACAND (candesartan cilexetil), prodrug, is hydrolyzed to candesartan during absorption from the gastrointestinal tract. Candesartan is selective AT1 subtype angiotensin II receptor antagonist.
Candesartan cilexetil, nonpeptide, is chemically described as (?)-1-Hydroxyethyl 2-ethoxy-1-[p-(o -1H -tetrazol-5-ylphenyl)benzyl]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester).
Mechanism of Action
Angiotensin II is formed from angiotensin in reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis.


INDICATIONS AND USAGE
1.1 Hypertension
ATACAND is indicated for the treatment of hypertension in adults and in children to <17 years of age, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from wide variety of pharmacologic classes including the class to which this drug principally belongs.
Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program?s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).
1.2 Heart Failure
ATACAND is indicated for the treatment of heart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction 40%) to reduce cardiovascular death and to reduce heart failure hospitalizations ATACAND also has an added effect on these outcomes when used with an ACE inhibitor.
DOSAGE AND ADMINISTRATION
2.1 Adult Hypertension
Dosage must be individualized. Blood pressure response is dose related over the range of to 32 mg. The usual recommended starting dose of ATACAND is 16 mg once daily when it is used as monotherapy in patients who are not volume depleted. ATACAND can be administered once or twice daily with total daily doses ranging from mg to 32 mg. Larger doses do not appear to have greater effect, and there is relatively little experience with such doses. Most of the antihypertensive effect is present within weeks, and maximal blood pressure reduction is generally obtained within to weeks of treatment with ATACAND.
Use in Hepatic Impairment: Initiate with mg ATACAND in patients with moderate hepatic insufficiency. Dosing recommendations cannot be provided for patients with severe hepatic insufficiency.
DOSAGE FORMS AND STRENGTHS
4 mg are white to off-white, circular/biconvex-shaped, non-film-coated scored tablets, coded ACF on one side and 004 on the other.
8 mg are light pink, circular/biconvex-shaped, non-film-coated scored tablets, coded ACG on one side and 008 on the other.
16 mg are pink, circular/biconvex-shaped, non-film-coated scored tablets, coded ACH on one side and 016 on the other.
32 mg are pink, circular/biconvex-shaped, non-film-coated scored tablets, coded ACL on one side and 032 on the other.
CONTRAINDICATIONS
ATACAND is contraindicated in patients who are hypersensitive to candesartan.
Do not co-administer aliskiren with ATACAND in patients with diabetes
WARNINGS AND PRECAUTIONS
5.1 Fetal Toxicity
Pregnancy Category D
Morbidity in Infants
Children 1 year of age must not receive ATACAND for hypertension. Drugs that act directly on the renin-angiotensin system (RAS) can have effects on the development of immature kidneys.
Hypotension
ATACAND can cause symptomatic hypotension.
Impaired Renal Function
Monitor renal function periodically in patients treated with ATACAND. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system. Patients whose renal function may depend, in part, on the activity of the renin-angiotensin system (e.g., patient with renal artery stenosis, chronic kidney disease, severe heart failure, or volume depletion) may be at particular risk of developing oliguria, progressive azotemia or acute renal failure when treated with ATACAND. Consider withholding or discontinuing therapy in patients who develop clinically significant decrease in renal function on ATACAND.
Hyperkalemia
Drugs that inhibit the renin-angiotensin system can cause hyperkalemia.
?Concomitant use of ATACAND with drugs that may increase potassium levels may increase the risk of hyperkalemia
DRUG INTERACTIONS
Agents Increasing Serum Potassium
Lithium
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors)
Combination Blockade of the Renin-Angiotensin System (RAS)
Pregnancy
Pregnancy Category D



NDC No.NEW 62559-0643-90 62559-643-90 OLD 00186-0032-54 UPC/GTIN No.3-62559-64390-0 MPN 3900  Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometr
Atacand 32mg Tab 90 by ANI Pharma
NDC No.NEW 62559-0643-90 62559-643-90 OLD 00186-0032-54 UPC/GTIN No.3-62559-64390-0 MPN 3900 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometr

Astra Zeneca Pharma
Atacand 32mg Tab 90 by ANI Pha
Astra Zeneca Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CANDESARTAN CILEXETIL ORA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.