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Rx Item-Asmanex Twist 110Mcg(30) Inh 30 by Merck

NDC No.00085-1461-02 UPC/GTIN No.3-00851-46102-4 MPN 146102 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical TherapiMerck & Co.Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Asmanex Twist 110Mcg(30) Inh 30 by Merck

$365.99$235.99

NDC No.00085-1461-02 UPC/GTIN No.3-00851-46102-4 MPN 146102 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No.Rx636631 Asmanex Twist 110Mcg(30) Inh 30 by Merck Item No.3636631 NDC No.00085146102 UPC No.300851461024 Other Name Mometasone Furoate Therapeutic Code 481008 Therapeutic Class Orally Inhaled

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ASMANEX HFA- mometasone furoate aerosol
Merck Sharp Dohme Corp.
DESCRIPTION
ASMANEX HFA is metered dose inhaler for oral inhalation only, consisting of 100 mcg and 200 mcg of mometasone furoate per actuation.
Mometasone furoate, the active component of ASMANEX HFA, is corticosteroid having the chemical name 9,21-dichloro-11(Beta),17-dihydroxy-16 (alpha)-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)
Mometasone furoate is white powder with an empirical formula of C27 H30 Cl2 O6 and molecular weight 521.44. It is practically insoluble in water; slightly soluble in methanol, ethanol, and isopropanol; soluble in acetone.
Each ASMANEX HFA 100 mcg and 200 mcg is hydrofluoroalkane (HFA-227: 1,1,1,2,3,3,3-heptafluoropropane) propelled pressurized metered dose inhaler containing sufficient amount of drug for 120 actuations
ASMANEX HFA should be primed before using for the first time by releasing test sprays into the air, away from the face, shaking well before each spray. In cases where the inhaler has not been used for more than days, prime the inhaler again by releasing test sprays into the air, away from the face, shaking well before each spra
Mechanism of Action
Mometasone furoate is corticosteroid demonstrating potent anti-inflammatory activity. The precise mechanism of corticosteroid action on asthma is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have wide range of inhibitory effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation and in the asthmatic response. These anti-inflammatory actions of corticosteroids may contribute to their efficacy in asthma.

Treatment of Asthma
ASMANEX? HFA is indicated for the maintenance treatment of asthma as prophylactic therapy in patients 12 years of age and older.
Important Limitations of Use
ASMANEX HFA is NOT indicated for the relief of acute bronchospasm.
2 DOSAGE AND ADMINISTRATION
2.1 General
ASMANEX HFA should be administered only by the orally inhaled route [see Instructions for Use in the Patient info. leaflet]. After each dose, the patient should be advised to rinse his/her mouth with water without swallowing.
The cap from the mouthpiece of the actuator should be removed before using ASMANEX HFA.
ASMANEX HFA should be primed before using for the first time by releasing test sprays into the air, away from the face, shaking well before each spray. In cases where the inhaler has not been used for more than days, prime the inhaler again by releasing test sprays into the air, away from the face, shaking well before each spray.
The ASMANEX HFA canister should only be used with the ASMANEX HFA actuator. The ASMANEX HFA actuator should not be used with any other inhalation drug product. Actuators from other products should not be used with the ASMANEX HFA canister.
2.2 Dosing
ASMANEX HFA should be administered as two inhalations twice daily every day (morning and evening) by the orally inhaled route.
Shake well prior to each inhalation.
The recommended doses for ASMANEX HFA treatment based on prior asthma therapy are provided in Table 1.
Previous Therapy
Recommended Dose
*
For Patients Currently Receiving Chronic Oral Corticosteroid Therapy: Prednisone should be weaned slowly, beginning after at least week of ASMANEX HFA therapy. Monitor patients carefully for signs of asthma instability, including serial objective measures of airflow, and for signs of adrenal insufficiency during steroid taper and following discontinuation of oral corticosteroid therapy [see Warnings and Precautions ].
Inhaled medium-dose corticosteroids
ASMANEX HFA 100 mcg, inhalations twice daily
Inhaled high-dose corticosteroids
ASMANEX HFA 200 mcg, inhalations twice daily
Oral corticosteroids *
ASMANEX HFA 200 mcg, inhalations twice daily
If dosage regimen of ASMANEX HFA fails to provide adequate control of asthma, the therapeutic regimen should be re-evaluated and additional therapeutic options, e.g., replacing the current strength of ASMANEX HFA with higher strength, initiating an inhaled corticosteroid and long-acting beta2 -agonist combination product, or initiating oral corticosteroids, should be considered.
The maximum daily recommended dose is two inhalations of ASMANEX HFA 200 mcg twice daily (maximum of 800 mcg day). If symptoms arise between doses, an inhaled short-acting beta2 -agonist should be taken for immediate relief.
The maximum benefit may not be achieved for week or longer after beginning treatment. Individual patients may experience variable time to onset and degree of symptom relief. For patients who do not respond adequately after weeks of therapy, higher strength may provide additional asthma control.
After asthma stability has been achieved, it is desirable to titrate to the lowest effective dosage to reduce the possibility of side effects.
3 DOSAGE FORMS AND STRENGTHS
ASMANEX HFA is pressurized metered dose inhaler that is available in strengths.
ASMANEX HFA 100 mcg delivers 100 mcg of mometasone furoate per actuation.
ASMANEX HFA 200 mcg delivers 200 mcg of mometasone furoate per actuation.
4 CONTRAINDICATIONS
4.1 Status Asthmaticus
ASMANEX HFA is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.
ADVERSE REACTIONS
Systemic and local corticosteroid use may result in the following:
Candida albicans infection
Immunosuppression
Hypercorticism and adrenal suppression
Growth effects in pediatrics
Glaucoma and cataracts
DRUG INTERACTIONS
In clinical trials, concurrent administration of ASMANEX HFA and other drugs, such as short-acting beta2 -agonist and intranasal corticosteroids have not resulted in an increased frequency of adverse drug reactions. No formal drug interaction studies have been performed with ASMANEX HFA.
7.1 Inhibitors of Cytochrome P450 3A4
The main route of metabolism of corticosteroids, including mometasone furoate, is via CYP3A4. After oral administration of ketoconazole, strong inhibitor of CYP3A4, the mean plasma concentration of orally inhaled mometasone furoate increased. Concomitant administration of CYP3A4 inhibitors may inhibit the metabolism of, and increase the systemic exposure to, mometasone furoate. Caution should be exercised when considering the coadministration of ASMANEX HFA with long-term ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin


NDC No.00085-1461-02 UPC/GTIN No.3-00851-46102-4 MPN 146102 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapi
Asmanex Twist 110Mcg(30) Inh 30 by Merck
NDC No.00085-1461-02 UPC/GTIN No.3-00851-46102-4 MPN 146102 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapi

Merck & Co.
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Merck & Co.

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MOMETASONE FUROATE INHALA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.