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Rx Item-Aricept 10mg Donepezil Tab 30 by Eisai

RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Aricept 10mg Donepezil Tab 30 by Eisai

$607.32$599.99

RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No.Rx046839 Aricept 10mg Tab 30 by Eisai Item No.3046839 NDC No.62856024630 UPC No.362856246309 Other Name Donepezi

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Clinical Information
Gen. Code and Des.
29334 donepezil HCl ORAL TABLET 10 MG
GCN and Des.
4300 donepezil HCl ORAL TABLET 10 MG
Strength
10MG
Dose Form
TABLET
Product Category
RX Pharmaceuticals
Fine Line Class
850085008510 All Rx Products
DEA Class
NC
OMP Family

AHFS Class
12040000 PARASYMPATHOMIMETIC (CHOLINERGIC AGENTS)
Active Ingredients
6296 donepezil HCl 120011703
Inactive Ingredients
2432 lactose 64044515




ARICEPT-DONEPEZIL donepezil hydrochloride tablet
ARICEPT (donepezil hydrochloride) is reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (?)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H -inden-1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24 H29 NO3 HCl and molecular weight of 415.96. Donepezil hydrochloride is white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane
INDICATIONS AND USAGE
ARICEPT is indicated for the treatment of dementia of the Alzheimer?s type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer?s disease.
2 DOSAGE AND ADMINISTRATION
2.1 Dosing in Mild to Moderate Alzheimer?s isease
The recommended starting dosage of ARICEPT is mg administered once per day in the evening, just prior to retiring. The maximum recommended dosage of ARICEPT in patients with mild to moderate Alzheimer?s disease is 10 mg per day. dose of 10 mg should not be administered until patients have been on daily dose of mg for to weeks.
2.2 Dosing in Moderate o Severe Alzheimer?sD isease
The recommended starting dosage of ARICEPT is mg administered once per day in the evening, just prior to retiring. The maximum recommended dosage of ARICEPT in patients with moderate to severe Alzheimer?s disease is 23 mg per day. dose of 10 mg should not be administered until patients have been on daily dose of mg for to weeks. dose of 23 mg per day should not be administered until patients have been on daily dose of 10 mg for at least months.
2.3 Administration info.
ARICEPT should be taken in the evening, just prior to retiring. ARICEPT can be taken with or without food.
The ARICEPT 23 mg tablet should not be split, crushed, or chewed.
Allow ARICEPT ODT to dissolve on the tongue and follow with water.
3 DOSAGE FORMS AND STRENGTHS
ARICEPT is supplied as film-coated, round tablets containing mg, 10 mg, or 23 mg of donepezil hydrochloride.
The mg tablets are white. The strength, in mg , is debossed on one side and ARICEPT is debossed on the other side.

The 10 mg tablets are yellow. The strength, in mg (10), is debossed on one side and ARICEPT is debossed on the other side.

The 23 mg tablets are reddish. The strength, in mg (23), is debossed on one side, and ARICEPT is debossed on the other side.
ARICEPT ODT is supplied as round tablets containing either mg or 10 mg of donepezil hydrochloride.
The mg orally disintegrating tablets are white. The strength, in mg , is debossed on one side and ARICEPT is debossed on the other side.

The 10 mg orally disintegrating tablets are yellow. The strength, in mg (10), is debossed on one side and ARICEPT is debossed on the other side.
4 CONTRAINDICATIONS
ARICEPT is contraindicated in patients with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.
5 WARNINGS AND PRECAUTIONS
5.1 Anesthesia
ARICEPT, as cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.
Cardiovascular Conditions
Nausea and Vomiting
Peptic Ulcer Disease and GI Bleeding
Weight Loss
Genitourinary Conditions
Neurological Conditions: Seizures
Pulmonary Conditions
DRUG INTERACTIONS
7.1 Use with Anticholinergics
Because of their mechanism of action, cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications.
7.2 Use with Cholinomimetics and Other Cholinesterase Inhibitors
A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists such as bethanechol
Pregnancy
Pregnancy Category C
Mechanism of Action
Current theories on the pathogenesis of the cognitive signs and symptoms of Alzheimer?s disease attribute some of them to deficiency of cholinergic neurotransmission.
Donepezil hydrochloride is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. There is no evidence that donepezil alters the course of the underlying dementing process.
ATIENT COUNSELING info.
Advise the patient to read the FDA-approved patient labeling (Patient info.).
Instruct patients and caregivers to take ARICEPT only once per day, as prescribed.
Instruct patients and caregivers that ARICEPT can be taken with or without food. ARICEPT 23 mg tablets should be swallowed whole without the tablets being split, crushed or chewed. ARICEPT ODT should not be swallowed whole, but be allowed to dissolve on the tongue and followed with water.
Advise patients and caregivers that ARICEPT may cause nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and decreased appetite.
ARICEPT PATIENT PACKAGE INSERT

ARICEPT? (Air-eh-sept)
(donepezil hydrochloride) tablets
Tablets: mg, 10 mg, and 23 mg
ARICEPT ODT (Air-eh-sept oh-dee-tee)
(donepezil hydrochloride) orally disintegrating tablets
ODT Tablets: mg and 10 mg
Read the Patient info. that comes with ARICEPT before the patient starts taking it and each time you get refill. There may be new info.. This leaflet does not take the place of talking with the doctor about Alzheimer?s disease or treatment for it. If you have questions, ask the doctor or pharmacist.
What is ARICEPT?
ARICEPT comes as ARICEPT film-coated tablets in dosage strengths of mg, 10 mg, and 23 mg, and as ARICEPT Orally Disintegrating Tablets (ODT; mg and 10 mg). Except where indicated, all the info. about ARICEPT in this leaflet also applies to ARICEPT ODT.
ARICEPT is prescription medicine to treat mild, moderate, and severe Alzheimer?s disease. ARICEPT can help with mental function and with doing daily tasks. ARICEPT does not work the same in all people. Some people may:
Seem much better

Get better in small ways or stay the same

Get worse over time but slower than expected

Not change and then get worse as expected
ARICEPT does not cure Alzheimer?s disease. All patients with Alzheimer?s disease get worse over time, even if they take ARICEPT.
ARICEPT has not been approved as treatment for any medical condition in children.
Who should not take ARICEPT?
The patient should not take ARICEPT if allergic to any of the ingredients in ARICEPT or to medicines that contain piperidines. Ask the patient?s doctor if you are not sure. See the end of this leaflet for list of ingredients in ARICEPT.
What should tell the doctor before the patient takes ARICEPT?
Tell the doctor about all the patient?s present or past health problems. Include:
Any heart problems including problems with irregular, slow, or fast heartbeats

Asthma or lung problems

A seizure

Stomach ulcers

Difficulty passing urine

Liver or kidney problems

Trouble swallowing tablets

Present pregnancy or plans to become pregnant. It is not known if ARICEPT can harm an unborn baby.

Present breast-feeding. It is not known if ARICEPT passes into breast milk. ARICEPT is not for women who are breast-feeding.
Tell the doctor about all the medicines the patient takes including prescription and non-prescription medicines, vitamins, and herbal products. ARICEPT and other medicines may affect each other.
Be particularly sure to tell the doctor if the patient takes aspirin or medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). There are many NSAID medicines, both prescription and non-prescription. Ask the doctor or pharmacist if you are not sure if any of the patient?s medicines are NSAIDs. Taking NSAIDs and ARICEPT together may make the patient more likely to get stomach ulcers.
ARICEPT taken with certain medicines used for anesthesia may cause side effects. Tell the responsible doctor or dentist that the patient takes ARICEPT before the patient has:
surgery

medical procedures

dental surgery or procedures.
Know the medicines that the patient takes. Keep list of all the patient?s medicines. Show it to the doctor or pharmacist before the patient starts new medicine.
How should the patient take ARICEPT?
Give ARICEPT exactly as prescribed by the doctor. Do not stop ARICEPT or change the dose yourself. Talk with the doctor first.

Give ARICEPT one time each day. ARICEPT can be taken with or without food.

ARICEPT 23 mg tablets should be swallowed whole without the tablets being split, crushed, or chewed.

ARICEPT ODT melts on the tongue. The patient should drink some water after the tablet melts.

If you miss giving the patient dose of ARICEPT, just wait. Give only the next dose at the usual time. Do not give doses at the same time.

If ARICEPT is missed for days or more, talk with the doctor before starting again.

If the patient takes too much ARICEPT at one time, call the doctor or poison control center, or go to the emergency room right away.
What are the possible side effects of ARICEPT?
ARICEPT may cause the following serious side effects:
slow heartbeat and fainting. This happens more often in people with heart problems. Call the doctor right away if the patient faints while taking ARICEPT.

more stomach acid. This raises the chance of ulcers and bleeding, especially when taking ARICEPT 23 mg. The risk is higher for patients who had ulcers, or take aspirin or other NSAIDs.

worsening of lung problems in people with asthma or other lung disease.

seizures.

difficulty passing urine.
Call the doctor right away if the patient has:
fainting.

heartburn or stomach pain that is new or won?t go away.

nausea or vomiting, blood in the vomit, dark vomit that looks like coffee grounds.

bowel movements or stools that look like black tar.

new or worse asthma or breathing problems.

seizures.

difficulty passing urine.
The most common side effects of ARICEPT are:
nausea

diarrhea

not sleeping well

vomiting

muscle cramps

feeling tired

not wanting to eat
These side effects may get better after the patient takes ARICEPT for while This is not complete list of side effects with ARICEPT For more info., ask the doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should ARICEPT be stored?
Store ARICEPT at room temperature between 59? to 86?F (15? to 30?C).
Keep ARICEPT and all medicines out of the reach of children.
General info. about ARICEPT
Medicines are sometimes prescribed for conditions that are not mentioned in this Patient info. Leaflet. Do not use ARICEPT for condition for which it was not prescribed. Do not give ARICEPT to people other than the patient, even if they have the same symptoms as the patient, as it may harm them.
This leaflet summarizes the most important info. about ARICEPT. If you would like more info. talk with the patient?s doctor. You can ask your pharmacist or doctor for info. about ARICEPT that is written for health professionals. For more info., go to www.ARICEPT.com, or call 1-800-760-6029.
What are the ingredients in ARICEPT?
Active ingredient: donepezil hydrochloride
Inactive ingredients:
ARICEPT mg and 10 mg film-coated tablets: lactose monohydrate, cornstarch, microcrystalline cellulose, hydroxypropyl cellulose, and magnesium stearate. The film coating contains talc, polyethylene glycol, hypromellose, and titanium dioxide. Additionally, the 10 mg tablet contains yellow iron oxide (synthetic) as coloring agent.

ARICEPT 23 mg film-coated tablets: ethylcellulose, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, and methacrylic acid copolymer, Type C. The reddish color film coating includes ferric oxide, hypromellose 2910, polyethylene glycol 8000, talc, and titanium dioxide.

ARICEPT ODT mg and 10 mg tablets carrageenan, mannitol, colloidal silicon dioxide, and polyvinyl alcohol. The 10 mg tablet contains yellow iron oxide (synthetic) as coloring agent.
ARICEPT? is registered trademark used by Eisai Inc. under license from
Eisai R&D Management Co., Ltd

RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630
Aricept 10mg Tab 30 by Eisai
RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630

RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630
AmericanPharmaWholesale.com
RX046839 046839 NDC No.62856-0246-30 62856-246-30 6285624630 62856-246-30 UPC/GTIN No.3-62856-24630-9 362856-246309 362856246309 MPN 24630

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
DONEPEZIL HCL ORAL TABLET
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.