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RX ITEM-Anzemet 20mg/ml Vial 25ml by Aventis Pharma

NDC No.00088-1209-26 UPC/GTIN No.3-00881-20926-5 MPN 120926 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical TherapiAventis PharmaceuticalsOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Anzemet 20mg/ml Vial 25ml by Aventis Pharma

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NDC No.00088-1209-26 UPC/GTIN No.3-00881-20926-5 MPN 120926 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx818777 Anzemet 20mg/ml Vial 25ml by Aventis Pharma Item No.3818777 NDC No.00088120926 UPC No.300881209265 Other Name Dolasetron Mesylate Therapeutic Code 562220 Therapeutic Class 5-Ht3 Rec

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ANZEMET-ANZEMET- dolasetron mesylate injection
sanofi-aventis U.S. LLC
DESCRIPTION
ANZEMET (dolasetron mesylate) is an antinauseant and antiemetic agent. Chemically, dolasetron mesylate is (2?,6?,8?,9a?)-octahydro-3-oxo-2,6-methano-2H -quinolizin-8-yl-1H -indole-3-carboxylate monomethanesulfonate, monohydrate. It is highly specific and selective serotonin subtype (5-HT3 receptor antagonist both in vitro and in vivo.
The empirical formula is C19 H20 N2 O3 CH3 SO3 ? H2 O, with molecular weight of 438.50. Approximately 74% of dolasetron mesylate monohydrate is dolasetron base.
Dolasetron mesylate monohydrate is white to off-white powder that is freely soluble in water and propylene glycol, slightly soluble in ethanol, and slightly soluble in normal saline.
ANZEMET Injection is clear, colorless, nonpyrogenic, sterile solution for intravenous administration. Each milliliter of ANZEMET Injection contains 20 mg of dolasetron mesylate and 38.2 mg mannitol, USP, with an acetate buffer in water for injection. The pH of the resulting solution is 3.2 to 3.8.
ANZEMET Injection multidose vials contain clear, colorless, nonpyrogenic, sterile solution for intravenous administration. Each ANZEMET multidose vial contains 25 mL (500 mg) dolasetron mesylate. Each milliliter contains 20 mg dolasetron mesylate, 29 mg mannitol, USP, and mg phenol, USP, with an acetate buffer in water for injection. The pH of the resulting solution is 3.2 to 3.7.
Dolasetron mesylate and its active metabolite, hydrodolasetron (MDL 74,156), are selective serotonin 5-HT3 receptor antagonists not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema.
Anzemet Indications and USAge
ANZEMET Injection is indicated for the following:

the prevention of postoperative nausea and vomiting (PONV) in adults and children years and older. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, ANZEMET Injection is recommended even where the incidence of postoperative nausea and/or vomiting is low.When prophylaxis has failed, repeat dose should not be initiated as rescue therapy.

the treatment of postoperative nausea and/or vomiting in adults and children years and older.
CONTRAINDICATIONS
ANZEMET Injection solution administered intravenously is contraindicated in adult and pediatric patients for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy due to dose dependent QT prolongation.
DOSAGE AND ADMINISTRATION
Adults
The recommended intravenous dosage of ANZEMET Injection is 12.5 mg given as single dose approximately 15 minutes before the cessation of anesthesia (prevention) or as soon as nausea or vomiting presents (treatment).
Pediatric Patients
Intravenous Administration
The recommended intravenous dosage in pediatric patients to 16 years of age is 0.35 mg/kg, with maximum dose of 12.5 mg, given as single dose approximately 15 minutes before the cessation of anesthesia or as soon as nausea or vomiting presents. Safety and effectiveness in pediatric patients under years of age have not been established.
Oral Administration of the Intravenous Product
ANZEMET Injection solution may be mixed into apple or apple-grape juice for oral dosing in pediatric patients. When ANZEMET Injection solution is administered orally, the recommended oral dosage in pediatric patients to 16 years of age is 1.2 mg/kg up to maximum 100-mg dose given within hours before surgery. The diluted product may be kept up to hours at room temperature before use.
PATIENT COUNSELING info.
Patients should be informed that ANZEMET may cause serious cardiac arrhythmias such as QT prolongation or heart block. Patients should be instructed to tell their health care provider right away if they perceive change in their heart rate, if they feel lightheaded, or if they have syncopal episode.
Patients should be informed that the chances of developing serious cardiac arrhythmias such as QT prolongation and Torsade de Pointes or heart block are higher in the following people:
Patients with personal or family history of abnormal heart rhythms, such as congenital long QT syndrome
Patients with personal history of sick sinus syndrome, atrial fibrillation with slow ventricular response or myocardial ischemia
Patients who take medications that may prolong the PR interval, such as certain antihypertensives or medications that may prolong the QRS interval, such as antiarrythmic medications
Patients who take medications, such as diuretics, which may cause electrolyte abnormalities
Patients with hypokalemia or hypomagnesemia
Elderly patients
ANZEMET should be avoided in these patients, since they may be more at risk for cardiac arrhythmias such as QT prolongation and Torsade de Pointes.
Advise patients of the possibility of serotonin syndrome with concomitant use of Anzemet and another serotonergic agent such as medications to treat depression and migraines. Advise patients to seek immediate medical attention if the following symptoms occur: changes in mental status, autonomic instability, neuromuscular aberrations with or without gastrointestinal symptoms.

NDC No.00088-1209-26 UPC/GTIN No.3-00881-20926-5 MPN 120926 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapi
Anzemet 20mg/ml Vial 25ml by Aventis Pha
NDC No.00088-1209-26 UPC/GTIN No.3-00881-20926-5 MPN 120926 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapi

Aventis Pharmaceuticals
AmericanPharmaWholesale.com
Aventis Pharmaceuticals

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
DOLASETRON MESYLATE INTRA
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.