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RX ITEM-Amturnide 150 5 12.5 Tab 30 by Novartis

NDC No.00078-0610-15 UPC/GTIN No.3-00780-61015-5 MPN 61015 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical TherapisNovartis Pharma CorpOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Amturnide 150 5 12.5 Tab 30 by Novartis

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NDC No.00078-0610-15 UPC/GTIN No.3-00780-61015-5 MPN 61015 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx069872 Amturnide 150/5/12.5 Tab 30 by Novartis Item No.3069872 NDC No.00078061015 UPC No.300780610155 Other Name Aliskiren-Amlodipine-Hctz Therapeutic Code 243240 Therapeutic Class Anti-Hype

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WARNING: FETAL TOXICITY
When pregnancy is detected, discontinue Amturnide as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.


INDICATIONS AND USAGE
Amturnide is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from wide variety of pharmacologic classes, including amlodipine and hydrochlorothiazide (HCTZ). There are no controlled trials demonstrating risk reduction with Amturnide.
DOSAGE AND ADMINISTRATION
2.1 General Considerations
Dose once-daily. The dosage may be increased after weeks of therapy. The maximum recommended dose of Amturnide is 300/10/25 mg.
Add-on/Switch Therapy
Use Amturnide for patients not adequately controlled with any of the following: aliskiren, dihydropyridine calcium channel blockers, and thiazide diuretics.
Switch patient who experiences dose-limiting adverse reactions attributed to an individual component?while on any dual combination of the components of Amturnide?to Amturnide at lower dose of that component to achieve similar blood pressure reductions.
2.3 Replacement Therapy
For patients receiving aliskiren, amlodipine, and HCTZ from separate tablets, substitute Amturnide containing the same component doses.
2.4 Relationship to Meals
Patients should establish routine pattern for taking Amturnide, either with or without meal. High-fat meals decrease absorption of aliskiren substantially [see Clinical Pharmacology (12.3)].
3 DOSAGE FORMS AND STRENGTHS
Tablets are convex ovaloid with beveled edge, film-coated, and unscored, in the following strengths:
Aliskiren Amlodipine /HCTZ (mg)
Color
Embossing Side 1/side 2
150/5/12.5
Violet white
YIY/NVR
300/5/12.5
Light pink
LIL/NVR
300/5/25
Pale orange brown
OIO/NVR
300/10/12.5
Light red
UIU/NVR
300/10/25
Brown
VIV/NVR
Mechanism of Action
Amturnide
The effects of combined treatment of aliskiren, amlodipine and HCTZ arise from the actions of these agents on different but complementary mechanisms that regulate blood pressure. Together, inhibition of the RAAS, inhibition of calcium channel-mediated vasoconstriction, and increase of sodium chloride excretion lowers blood pressure to greater degree than the individual components.
Aliskiren
Renin is secreted by the kidney in response to decreases in blood volume and renal perfusion. Renin cleaves angiotensinogen to form the inactive decapeptide angiotensin (Ang I). Ang is converted to the active octapeptide angiotensin II (Ang II) by ACE and non-ACE pathways.
PATIENT COUNSELING info.
Advise the patient to read the FDA-approved patient labeling (Patient info.).
Pregnancy
Advise female patients of childbearing age about the consequences of exposure to Amturnide during pregnancy. Discuss treatment options with women planning to become pregnant. Advise patients to report pregnancies to their physicians as soon as possible.
Symptomatic Hypotension
Caution patients receiving Amturnide that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician. Tell patients that if syncope occurs, discontinue Amturnide until the physician has been consulted.
Caution all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.
Anaphylactic Reactions and Angioedema
Advise patients to immediately report any signs or symptoms suggesting severe allergic reaction (difficulty breathing or swallowing, tightness of the chest, hives, general rash, swelling, itching, dizziness, vomiting, or abdominal pain) or angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician. Angioedema, including laryngeal edema, may occur at any time during treatment with Amturnide.
Potassium Supplements
Tell patients receiving Amturnide not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.
Relationship to Meals
Advise patients to establish routine pattern for taking Amturnide either with or without meal. High-fat meals decrease absorption substantially.

NDC No.00078-0610-15 UPC/GTIN No.3-00780-61015-5 MPN 61015 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapis
Amturnide 150 5 12.5 Tab 30 by Novartis
NDC No.00078-0610-15 UPC/GTIN No.3-00780-61015-5 MPN 61015 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapis

Novartis Pharma Corp
AmericanPharmaWholesale.com
Novartis Pharma Corp

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ALISKIREN/AMLODIPIN/HCTHI
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.