Aminosyn
AMINOSYN- isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, valine, alanine, arginine, histidine, proline, serine, tyrosine, glycine, sodium chloride, potassium acetate, phosphoric acid and magnesium acetate injection, solution
AMINOSYN- isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, valine, alanine, arginine, histidine, proline, serine, tyrosine, glycine, sodium chloride, magnesium chloride, sodium phosphate, dibasic and potassium chloride injection, solution
Hospira, Inc.
Sulfite-Free
A CRYSTALLINE AMINO ACID SOLUTION WITH ELECTROLYTES
Flexible Plastic Container
DESCRIPTION
Aminosyn? WITH ELECTROLYTES, Sulfite-Free, (a crystalline amino acid solution with electrolytes) is sterile, nonpyrogenic solution for intravenous infusion. Aminosyn WITH ELECTROLYTES is oxygen sensitive. Three different formulations are available.
Aminosyn FormulationsEssential Amino Acids (mg/100 mL)
Aminosyn
3.5% M*
7% WITHELECTROLYTES
8.5% WITHELECTROLYTES
Isoleucine
252
510
620
Leucine
329
660
810
Lysine (acetate)**
252
510
624
Methionine
140
280
340
Phenylalanine
154
310
380
Threonine
182
370
460
Tryptophan
56
120
150
Valine
280
560
680
* Contains maintenance electrolytes.
** Amount cited is for lysine alone and does not include the acetate salt.
Nonessential Amino Acids (mg/100 mL)
Aminosyn
3.5% M*
7% WITHELECTROLYTES
8.5% WITHELECTROLYTES
Alanine
448
900
1100
Arginine
343
690
850
Histidine
105
210
260
Proline
300
610
750
Serine
147
300
370
Tyrosine
31
44
44
Glycine
448
900
1100
* Contains maintenance electrolytes.
CLINICAL PHARMACOLOGY
Aminosyn WITH ELECTROLYTES, Sulfite-Free, (a crystalline amino acid solution with electrolytes) provides crystalline amino acids to promote protein synthesis and wound healing, and to reduce the rate of endogenous protein catabolism. Aminosyn WITH ELECTROLYTES, given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN). Aminosyn WITH ELECTROLYTES, can also be administered by peripheral vein with dextrose and maintenance electrolytes. Intravenous fat emulsion may be substituted for part of the carbohydrate calories during either TPN or peripheral vein administration of Aminosyn WITH ELECTROLYTES.
DOSAGE AND ADMINISTRATION
The total daily dose of the solution depends on the daily protein requirements and on the patient?s metabolic and clinical response. In many patients, provision of adequate calories in the form of hypertonic dextrose may require the administration of exogenous insulin to prevent hyperglycemia and glycosuria. To prevent rebound hypoglycemia, solution containing 5% dextrose should be administered when hypertonic dextrose infusions are abruptly discontinued.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. COLOR VARIATION FROM PALE YELLOW TO YELLOW IS NORMAL AND DOES NOT ALTER EFFICACY
Store at 20 to 25?C (68 to 77?F). [See USP Controlled Room Temperature.] Protect from freezing. Avoid exposure to light.