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Actos 15Mg 30 Tab By Takeda Pharm N. America Inc.

Item No.: RX381558 ACTOS         15MG     30    TAB by TAKEDA PHARM N. AMERICA  INC.   NDC No.: 64764015104,  64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104Item No.: RX381558 ACTOS         15MG     30    TAB by TAKEDA PHARM N. AMERICA  INC.   NDC No.: 64764015104,  64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Actos 15Mg 30 Tab By Takeda Pharm N. America Inc.

$466.28$431.74

Item No.: Rx381558 Actos 15Mg 30 Tab By Takeda Pharm N. America Inc. Ndc No.: 64764015104, 64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 Upc No.: 64764015104' 36476415104, 64764015104, 3-64764-15104-1, 364764151041 Generic Name: Pioglitazone Hcl Oral Tab Mfg. Name: Takeda Pharm N. America Inc. , 46628000 Mpn No.; 15104 Brand: Y Item Category: Rx Upc Last Check Digit: -1

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ACTOS- pioglitazone hydrochloride tablet

WARNING: CONGESTIVE HEART FAILURE

  • Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients (see WARNINGS). After initiation of ACTOS, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop, the heart failure should be managed according to the current standards of care. Furthermore, discontinuation or dose reduction of ACTOS must be considered.
  • ACTOS is not recommended in patients with symptomatic heart failure. Initiation of ACTOS in patients with established NYHA Class III or IV heart failure is contraindicated (see CONTRAINDICATIONS and WARNINGS).
  • ACTOS (pioglitazone hydrochloride) is an oral antidiabetic agent that acts primarily by decreasing insulin resistance. ACTOS is used in the management of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies indicate that ACTOS improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control while reducing circulating insulin levels.

    Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione monohydrochloride belongs to a different chemical class and has a different pharmacological action than the sulfonylureas, metformin, or the α-glucosidase inhibitors. The molecule contains one asymmetric carbon, and the compound is synthesized and used as the racemic mixture. The two enantiomers of pioglitazone interconvert in vivo. No differences were found in the pharmacologic activity between the two enantiomers.

  • Pioglitazone hydrochloride is an odorless white crystalline powder that has a molecular formula of C19 H20N2 O3 S•HCl and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide, slightly soluble in anhydrous ethanol, very slightly soluble in acetone and acetonitrile, practically insoluble in water, and insoluble in ether.

    ACTOS is available as a tablet for oral administration containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF, carboxymethylcellulose calcium NF, and magnesium stearate NF.

    CLINICAL PHARMACOLOGY

    Mechanism of Action

    ACTOS is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. ACTOS decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.

  • INDICATIONS AND USAGE

    ACTOS is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

  • DOSAGE AND ADMINISTRATION

    ACTOS should be taken once daily without regard to meals.

    The management of antidiabetic therapy should be individualized. Ideally, the response to therapy should be evaluated using HbA1c which is a better indicator of long-term glycemic control than FPG alone. HbA1creflects glycemia over the past two to three months. In clinical use, it is recommended that patients be treated with ACTOS for a period of time adequate to evaluate change in HbA1c (three months) unless glycemic control deteriorates. After initiation of ACTOS or with dose increase, patients should be carefully monitored for adverse events related to fluid retention (see BOXED WARNING and WARNINGS)

Item No.: RX381558 ACTOS         15MG     30    TAB by TAKEDA PHARM N. AMERICA  INC.   NDC No.: 64764015104,  64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104
RX381558
Item No.: RX381558 ACTOS 15MG 30 TAB by TAKEDA PHARM N. AMERICA INC. NDC No.: 64764015104, 64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104

Item No.: RX381558 ACTOS         15MG     30    TAB by TAKEDA PHARM N. AMERICA  INC.   NDC No.: 64764015104,  64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104
RX381558
Item No.: RX381558 ACTOS 15MG 30 TAB by TAKEDA PHARM N. AMERICA INC. NDC No.: 64764015104, 64764-0151-04, 64764015104, 64764-0151-04, 64764-01-5104, 64764015104 UPC No.: 64764015104

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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.